Company Overview

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures.

The Role

We are looking for a Bioinformatics Associate to join our team and contribute to the analysis of NGS datasets with a focus on gene editing applications. At Profluent, we work at the intersection of AI-driven protein design and cutting-edge gene editing technologies. In this role, you’ll work closely with experimental scientists, providing computational support and developing custom bioinformatics tools to analyze high-throughput sequencing data.

This is an excellent opportunity to shape the future of AI-driven protein design and to work cross-functionally with a diverse team of experts across machine learning, protein engineering, cell biology, and gene editing.

Responsibilities

• Collaborate with experimental scientists to analyze data from high-throughput gene editing experiments.
• Develop custom bioinformatics tools for processing and analyzing NGS sequencing data, ensuring scalability and robustness.
• Support experimental biology workflows, including guide RNA design, primer design, barcoding, library design, and more.
• Automate bioinformatics workflows using scripting languages (e.g., Python, Bash) and manage scalable cloud pipelines for large-scale data analysis.
• Document code clearly and communicate findings and insights to colleagues, presenting complex data in clear, actionable formats.

Qualifications

• BS or MS in Bioinformatics, Computer Science, or a related field in quantitative biosciences.
• 2+ years of academic or industry experience in bioinformatics or a related field.
• Proficiency in Python, including familiarity with data analysis libraries (e.g., numpy, pandas, Jupyter notebooks, biopython).
• Experience with bioinformatics sequence analysis tools and methodologies.
• Experience with Linux environments and version control (git).
• Hands-on experience analyzing data from molecular biology experiments.
• Proficiency with at least one data analysis and visualization tool (e.g., R, matplotlib, seaborn).
• Strong organizational skills, attention to detail, and the ability to thrive in a fast-paced environment.

Preferred (but not required)

• Experience with cloud-based platforms (e.g., Google Cloud Platform, AWS) for data processing and storage.
• Familiarity with workflow orchestration tools (e.g., Nextflow, snakemake)
• Familiarity with containerization (e.g., Docker, Kubernetes) for scalable data processing.

What we offer at Profluent (aside from a fulfilling journey with awesome people)…

• A high-growth opportunity with meaningful impact
• Competitive compensation package
• Health insurance (health/dental/vision)
• Generous paid time off (PTO) policy
• Commitment to physical and mental well-being
• More benefits and perks to be announced shortly!

Profluent Bio is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.