Protein Engineer

Ginkgo Bioworks

Boston, MA, US
  • Job Type: Full-Time
  • Function: Web/Graphic Design/Internet
  • Post Date: 01/14/2021
  • Website: ginkgobioworks.com
  • Company Address: 27 Drydock Avenue 8th Floor, Boston, MA, 02210

About Ginkgo Bioworks

Headquartered in Boston, Ginkgo Bioworks uses the most advanced technology on the planet – biology – to grow products instead of manufacturing them. We design custom microbes for customers across multiple markets, and build our foundries to scale the process of organism engineering using software and hardware automation.

Job Description

Ginkgo is building an industrialized foundry for organism engineering. Our first foundry, Bioworks1, launched in Spring 2015. We designed Bioworks1 to be capable of delivering many organisms to customers in many markets. Already, we're using Bioworks1 to concurrently develop 10+ organisms across multiple species and cultured ingredients. You can learn more about cultured ingredients here http://ginkgobioworks.com/markets/cultured-ingredients/

Key to the design of organisms for the production of cultured ingredients are the biosynthetic enzymes that make these natural products. We are seeking protein engineers interested in tackling the formidable challenge of developing our parts set for biosynthesis across microbial metabolism. As you develop this enzyme toolkit, you'll be tackling the full gamut of technical challenges: expression, solubility, localization, activity, substrate specificity, product profile and more. As such, you'll need to bring the complete repertoire of solutions to bear on these problems from synthetic metagenomics to directed evolution to rational protein engineering and more.
RESPONSIBILITIES

Functional expression of enzyme families and classes
Apply rational protein engineering, directed evolution, synthetic metagenomics and other approaches for enzyme redesign with the goal of improving expression, solubility, activity, substrate specificity and product profile
REQUIREMENTS

PhD or equivalent
Deep experience in enzyme catalysis
Deep experience in functional enzyme expression in microbial hosts
Experience in protein engineering or directed evolution
Experience in natural products chemistry and/or secondary metabolism a plus
Experience with HTP assays a plus
To learn more about Ginkgo, check out some recent press:

http://www.wired.com/2015/11/move-over-jony-ivebiologists-are-the-next-rock-star-designers/

http://fortune.com/2015/07/23/ginkgo-bioworks/

https://medium.com/the-os-fund/a-new-era-of-industrial-engineering-using-biology-dd4571aa6d27

http://www.fastcompany.com/3053065/most-creative-people/twist-bioscience-inks-deal-to-sell-100-million-pairs-of-synthetic-dna

We also feel it’s important to point out the obvious here – there’s a serious lack of diversity in our industry and it needs to change. Our goal is to help drive that change. We hope to continue to build a company whose culture promotes inclusion and embraces how rewarding it is to work with engineers from all walks of life. Making biology easier to engineer is a tough nut to crack - we can’t afford to leave any talent untapped.

It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.

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