Senior Scientist I/II- Medicinal Chemistry

Constellation Pharmaceuticals

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 06/03/2021
  • Website:
  • Company Address: 215 First Street, Suite 200, Cambridge, MA , 02142

About Constellation Pharmaceuticals

Constellation Pharmaceuticals is a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics that address serious unmet medical needs in patients with cancers associated with abnormal gene expression. Our integrated epigenetics platform enables us to validate targets and generate small molecules against these targets that selectively modulate gene expression in tumor and immune cells to drive anti-tumor activity. We are able to target a broad variety of epigenetic regulators using our platform and have generated development candidates acting against distinct classes of those regulators.

Job Description

Constellation Pharmaceuticals is a pioneering epigenetics company, focused on the development of novel molecules targeting chromatin regulatory proteins for therapeutic applications in oncology. We have small molecule therapeutics in various stages of clinical and preclinical development, including our lead product candidate, the BET-inhibitor pelabresib for myelofibrosis, and we are adding to our drug discovery team. We believe that each team member can impact and improve the lives of patients and that we are #BrighterTogether!

We are seeking a highly talented and experienced medicinal chemist to join our team. In addition to strong synthetic chemistry skills and the ability to lead from the bench, the ideal candidate will also have experience with multi-parameter optimization, a broad understanding of medicinal chemistry, and drug discovery with the experience to lead a multidisciplinary drug discovery team. The successful candidate will be independent, organized, detail-oriented, flexible, and enjoy working in a highly collaborative, fast-paced team environment.


In this role you will:

  • Design and develop medicinal chemistry strategies/approaches aimed at both improving potency while balancing favorable drug-like properties towards advancing our drug discovery portfolio
  • Collaborate with an internal team of synthetic, analytical, computational, and medicinal chemists in a new, state of the art chemistry lab
  • Collaborate with a network of global chemistry CRO partners
  • Participate in cross-functional drug discovery teams, with colleagues from several scientific disciplines (with the opportunity to co-lead projects)
  • Have the opportunity to patent, publish, and represent Constellation’s science externally
  • Contribute to a culture of problem-solving and continuous learning

We are looking for people who have:

  • D. in organic chemistry with a minimum of 6-15 years of industrial experience in medicinal chemistry
  • Excellent laboratory skills, with the ability to collaborate effectively with both internal and external chemistry teams
  • Ability to execute independently as well as collaborate with (or lead) a multidisciplinary team of medicinal chemists, biologists, pharmacologists, and external collaborators
  • Strong experience with structure-based drug design is preferred
  • Proficiency in elucidating and identifying structure activity relationships (SAR) to address potency, selectivity, ADME/PK, and in vivo efficacy
  • Proven track record of sustained high performance and innovative project contributions, including patents, presentations, and peer-reviewed publications.
  • Ability to engage and influence senior leadership in strategic discussions
  • Excellent oral/written communication and presentation skills

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.