Medicinal Chemistry Research Associate/ Senior Research Associate

Pliant Therapeutics

South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 06/02/2021
  • Website: pliantrx.com
  • Company Address: 260 Littlefield Avenue, South San Francisco, CA, 94080

About Pliant Therapeutics

Pliant Therapeutics is focused on discovering, developing and commercializing breakthrough treatments for fibrotic diseases.

By harnessing the therapeutic potential of integrin biology and TGF-β modulation, Pliant aims to prevent or even reverse fibrosis to address the needs of many patients. The company also aims to build a patient registry for certain areas of fibrotic disease to both increase understanding of natural disease progression, and fuel biomarker discovery.

Job Description

Company Overview

Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by fibrotic disease. The Company’s focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company’s lead product candidate, PLN-74809, is an oral, small molecule selective inhibitor of the αvβ1 and αvβ6 integrins that play a key role in multiple fibrotic pathways. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration in both idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC), and are currently in Phase 2a clinical trials for these indications. Pliant’s second product candidate, PLN-1474, is an oral, small molecule selective inhibitor of the αvβ1 integrin, in development as a potential treatment forlate-stage liver fibrosis under a partnership with Novartis. The Company also has discovery and development programs in oncology and muscular dystrophies. The Company is seeking passionate, creative, and dedicated individuals to join our team and contribute to our mission.

Description

 

Immediate openings are available for a Research Associate in Chemistry.  This individual will join a dynamic and growing multidisciplinary team focused on discovery and advancement of new drug candidates and disease biomarkers.  The primary responsibility of this position will be synthesis, purification, and characterization of novel biologically active molecules. The successful candidate will work with minimal supervision of a Senior Research Associate or Scientist.  The candidate will have the ability to use the chemical literature to plan and propose experiments and synthetic schemes and evaluate structure and purity of products using modern analytical techniques.

 

Responsibilities

 

  • Participate in the design, synthesis, purification, and characterization of novel biologically active molecules.
  • Contribute to exploratory research and lead optimization projects, and collaborate closely with colleagues in other groups.
  • Summarize/interpret data and present findings in research meetings.
  • Independently execute assigned tasks following appropriate laboratory/technical procedures under supervision.
  • Design and implement new laboratory techniques, troubleshoot experiments, and ensure experiments are well designed and performed to a high standard.

 

Qualifications

 

  • BS/MS in Chemistry with 5-7 years of relevant experience in synthetic organic/medicinal chemistry after the BS degree.
  • Potential to learn and adapt in a fast moving environment.
  • Demonstrated expertise in organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, MS, HPLC, etc.).
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
  • Demonstrated ability to work independently and perform well in a team environment.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.