Senior Medical Director

Kymera Therapeutics

Watertown, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 06/01/2021
  • Website:
  • Company Address: 400 Technology Square, 10Th Floor, Cambridge, MA, 02139

About Kymera Therapeutics

Kymera Therapeutics is a biotechnology company pioneering a transformative new approach to treating previously untreatable diseases. The company is advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade rather than inhibit dysregulated, disease-causing proteins. Powered by a proprietary predictive modeling capability and a game-changing integrated degradation platform, Kymera is accelerating drug discovery with an unmatched ability to target and degrade the most intractable of proteins, and advance new treatment options for patients.

Job Description

The Senior Medical Director will provide clinical leadership within Kymera in critical projects and will be a crucial link with investigators and key opinion leaders in the external oncology community. The incumbent will work closely with these experts, developing the clinical trial strategy and designing clinical trials. This individual will serve as a key strategic and medical point person during the conduct of the trials, monitoring safety of ongoing trials and leading efforts to analyze and present data from clinical studies.  The successful candidate will work closely with other physicians, scientists, regulatory professionals, statisticians and internal stakeholders to carry out these responsibilities.  This individual will respond to inquiries by practitioners and investigators, IRBs, regulatory bodies, and vendors.

Kymera Therapeutics is a clinical-stage biotechnology company focused on advancing the field of targeted protein degradation (TPD), a transformative new approach to address previously intractable disease targets. Kymera’s Pegasus™ TPD platform harnesses the body’s natural protein recycling machinery to degrade disease-causing proteins, with a focus on undrugged nodes in validated pathways currently inaccessible with conventional therapeutics. Our mission is to discover, develop, and commercialize transformative therapies while leading the evolution of targeted protein degradation. Kymera’s goal is to become a fully integrated biopharmaceutical company with a pipeline of novel medicines, with an initial focus on immune-inflammatory diseases and oncology.

In 2021, we plan to continue to grow and strengthen our organizational capabilities to deliver on the potential of inventing a new class of protein degrader medicines for patients. Kymera is rapidly advancing three programs in clinical studies this year. We are also actively advancing a broad pipeline of preclinical programs across a wide variety of diseases, both internally and in collaboration with our partners Sanofi and Vertex Pharmaceuticals.


    Provides clinical leadership and strategic medical input for all clinical deliverables in critical projects and clinical programs.
    Collaborates with physicians, scientists, regulatory professionals, biostatisticians, regulatory, executive staff and others as necessary to develop and execute clinical trials from beginning to end.
    Drives clinical trial execution to achieve timely completion of clinical studies in collaboration with clinical teams.
    Assumes medical responsibility for clinical trials including active participation in real-time medical monitoring of studies, including patient eligibility assessment, study design questions and safety data review.
    Conducts safety monitoring in collaboration with CRO pharmacovigilance group of active clinical studies.
    Ensures consistent practices with the highest ethical standards in compliance with internal SOPs, local regulations, and laws.
    Collaborates with colleagues in Regulatory Affairs, CMC, Toxicology, Research, and Pharmacology to respond to health authority and ethics committee queries.
    Participates in clinical study report writing and review, using medical expertise to identify ways to best analyze and present data.
    Designs and develops clinical study protocols and associated clinical study documents and contributes to program level documents such as Investigator Brochures and Clinical Development Plans.
    Performs functions in compliance with GCP, and good medical practice.
    Collaborates with Principal Investigators in the evaluation and assessment of publications (abstracts, posters, manuscripts) associated with clinical data.
    Networks extensively to develop long-term strategic partnerships with thought leaders both internally and externally, in support of Kymera’s vision.


    Medical degree (or equivalent) with board certification or board qualifications in medical oncology required.
    Board certification/eligibility and clinical experience in oncology or hematology/oncology highly preferred.
    Must have a minimum of 3 years of clinical development experience within the pharmaceutical or biotechnology industry with a focus and strong track record of experience leading oncology clinical trials.
    Academic oncologists with clinical and research experience relative to the oncology platform will be considered.
    Strong working knowledge of the clinical drug development process required.
    Must have a solid understanding of the clinical landscape relevant to oncology patients and health care practitioners in the field.
    Requires a track record in the conduct of/participation in clinical trials (investigator initiated, company sponsored or cooperative group trials) and their subsequent publications.
    Requires strong credibility within the US medical community including the ability to reach out to key thought leaders in academia.
    The demonstrated ability to work in a matrix environment with cross-functional teams is required.

Kymera Therapeutics is an equal opportunity employer and welcomes all job applicants. All qualified applicants will receive consideration for employment without discrimination based on race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.