Senior Scientist / Scientist, Human Genetics

Maze Therapeutics

South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 05/27/2021
  • Website: mazetx.com
  • Company Address: 123 Saginaw Drive, Redwood City, CA, 94063

About Maze Therapeutics

Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. We have assembled a world-class team that we need to realize this vision, including creative scientific pioneers in genetics, experienced company builders, and biotech industry leaders.

Job Description

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking an exceptional computational biologist/statistical geneticist to join our organization. The successful candidate will contribute to the design of robust genetic association and gene interaction studies, develop workflows/pipelines for association analyses and other statistical genetics techniques, perform analyses on large-scale genetic datasets, integrate results from functional genomics screens with human genetics and contribute to interpretation of results with the goal of identifying new therapeutic targets. Successful candidates will contribute directly to the development of novel disease modifying therapeutics.

Your Role in Navigating The Maze:

  • You will work in close collaboration with data science and functional genomics to integrate results from functional genomics studies with human genetics data for new target identification/prioritization
  • You will perform and interpret human genetic analyses using public and internal data to identify new targets and therapeutic hypotheses
  • You will contribute to writing patents, reports and scientific publications

Your Navigation Tools:

  • Ph.D., M.D. or M.D.-Ph.D. with significant relevant experience in bioinformatics/computational biology and the biologic interpretation of human genetic data
  • Well versed in the management and analysis of large datasets, including those derived from SNP arrays and next-generation sequencing platforms
  • Experience in the analysis of large-scale genomic association studies in complex genetic diseases including correcting for population stratification and imputation of genotypes.
  • A strong computational/statistical background (perl, python, R or others) is highly desirable
  • Experience with Mendelian Randomization (or other causality inference approaches) or analysis of CRISPR screens is a plus
  • Communication skills to clearly present data and your interpretation of the results

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.