Crystallographer (ProteoVant)

Roivant Sciences

Philadelphia, PA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 06/07/2021
  • Website: roivant.com
  • Company Address: 151 W 42nd Street, 15th Floor, New York, NY, 10036

About Roivant Sciences

Roivant aims to improve health by rapidly delivering innovative medicines and technologies to patients. We do this by building Vants – nimble, entrepreneurial biotech and healthcare technology companies with a unique approach to sourcing talent, aligning incentives, and deploying technology.

Job Description

Background:  

Roivant is a global biopharma company improving health by rapidly delivering innovative medicines and technologies to patients. We do this by building Vants - nimble, independent, entrepreneurial companies with a unique approach to sourcing talent, aligning incentives, and deploying technology. Roivant recently created a new Vant in Protein Degradation, ProteoVant Therapeutics, through the acquisition of a leading protein degradation company, the investment of its own capital and $200 million of outside capital, as well as the creation of an experienced management team to build ProteoVant into a leading, independent protein degrader company. 

Company Description:  

ProteoVant Therapeutics is a newly launched development-stage biotech company focusing on the discovery and development of disease-modifying therapies by harnessing natural protein homeostasis processes. We recently acquired numerous novel, protein degrader programs that are in discovery and preclinical development through our acquisition of Oncopia Therapeutics, Inc., a protein degradation company initially focused on oncology indications. Our lead program(s) in oncology may enter the clinic as early as late 2021.  The company recently secured $200M in funding from SK Holdings in addition to investment from Roivant Sciences.  

 In addition to ProteoVant's preclinical and discovery protein degrader programs and its deep relationship with the lab of Dr. Shaomeng Wang at the University of Michigan, Proteovant is enhancing its drug discovery engine to accelerate development by combining deep drugging expertise with innovative technology platforms including VantAI (Roivant's AI platform) and Silicon Therapeutics (Roivant's physics-driven drug design platform).  

 Our current therapeutic focus includes oncology, immunology, and CNS, with planned expansion into additional therapeutic areas in the near future. ProteoVant is rapidly expanding its discovery and development teams in biology, chemistry, biochemistry, DMPK, bioinformatics, toxicology and CMC at many levels. Our R&D organization is primarily located close to major pharmaceutical companies in the Philadelphia area where we are building state-of-the-art labs and office space. We also maintain offices in New York City, with remote work a possibility for certain positions. Please send your resumes or inquiries to [email protected] 

For additional information on ProteoVant please see our one-page overview - here  

Location: Pennsylvania, USA  

Reporting to: Head of Pre-Clinical R&D and Chief Scientific Officer 

Position Summary: 

She/He will lead the structure biology efforts, supporting drug discovery efforts within Proteovant's research and development department.  She/He will work closely with medicinal chemists and computational chemist in the drug design team. She/He will be a key member of the drug discovery project team. 

Key Responsibilities 

  • A member or leader of the structural biology group at Proteovant and will be responsible for the crystallization and the structure determination of protein-small molecule and protein-protein complexes by X-ray crystallography and cryoEM 
  • Responsible for construct design, biochemical and biophysical characterization, crystallization, X-ray data collection/refinement, structure determination, and analysis 
  • Work closely with protein scientists, biophysicists, and protein NMR scientists at Proteovant and at CROs 
  • Serve as a member of the drug discovery team, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule protein degraders. The candidate will be expected to be able to participate in experimental design and to conduct experiments independently and can supervise/interact with CRO scientists 
  • Responsible for completing projects independently and as part of a team and will be responsible for timely updates of the project progress to the project teams, both informally and by formal reports 

Requirements 

  • PhD degree in structural biology, protein biochemistry/biophysics, crystallography, or in a related discipline with experience in drug discovery 
  • Proven ability in all aspects of protein crystallography from construct design through structure determination and analysis 
  • Experience in the crystallization of protein-small molecule and protein-protein complexes 
  • Extensive experience in structure-based drug design (SBDD) utilizing X-ray crystallography 
  • Expertise in commonly used structural biology software packages 
  • Proficiency in protein biochemical and biophysical assays 
  • Excellent communication and witting skills 
  • Detail-oriented, highly organized and able to manage multiple tasks and deliver quality data 
  • Experience/knowledge in protein NMR and other biophysics techniques in protein structures and protein dynamics is a plus

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This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.