SRA – Immunohistochemistry (IHC)


Menlo Park, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 05/25/2021
  • Website:
  • Company Address: 1505 Obrien Drive, Suite A/D, Menlo Park, California 94025, US

About Synthekine

Synthekine, a biotechnology company focused on discovery and developing best in class cytokine therapeutics

Job Description

Synthekine is a biotechnology company focused on discovery and developing best in class cytokine therapeutics to treat cancer and autoimmune diseases. The company was founded by Dr. Chris Garcia, Stanford University Professor and Howard Hughes Medical investigator. Synthekine is based on our unique insights on how cytokines bind to their receptors and how these systems can be tuned through ligand engineering. Synthekine was formed in 2019 and has raised its Series A venture capital round from Canaan Partners, Samsara Biocapital, and The Column Group, three leading Bay Area biotech venture funds. The company is based in Menlo Park, CA and has built integrated research, manufacturing, and in-vivo pharmacology capabilities.

Synthekine is advancing a deep pipeline that includes several preclinical programs, including biased versions of Interleukin-2 and Interferon Gamma. These cytokines have been tuned to decouple anticancer and anti-inflammatory activity at the molecular level, a differentiated approach to developing selective therapeutics. In addition to these pre-clinical products, Synthekine is founded on multiple therapeutic platforms, including a platform that allows for non-natural pairing of cytokine receptors, potentially resulting in novel biology and unique therapeutics.


We are seeking an IHC expert at SRA level to work in the Department of Translational Pathology at our Menlo Park, CA location. Reporting to the Director of Translational Pathology, the candidate will perform routine IHC staining using previously optimized protocols as well as optimize new protocols as the needs arise. The individual will be part of a highly collaborative and dynamic startup team that will support pre-clinical and clinical research in inflammation, immunotherapy and oncology. Synthekine offers a competitive pay and benefits package commensurate with experience and skill level.

Academic Qualifications: Bachelor’s (BA or BS), Master’s degree in a relevant field.

Professional experience and desired Skills:
  • Minimum 3-4 years of hands-on experience in IHC single plex and multiplex staining and method development with various detections including fluorescence (Opal or Alexa-fluor based). Startup experience is preferred.
  • Experience with Leica Bond Rx and Dako Autostainer platforms.
  • Experience in managing and tracking multiple projects simultaneously.
  • Experience in documentation, analysis, interpretation and presentation of data generated from experiments with various statistical approaches.
  • Experience in presenting data in team meetings is preferred.
  • Excellent written and oral communication skills.
  • Experience with digital pathology/ imaging to capture relevant areas of interest and quantify the signal is highly desired.
  • Routine histology technical experience (tissue trimming, processing, embedding, sectioning) is highly desired.
Essential Job Duties for this position:
  • IHC staining and new method development on FFPE and frozen tissues from animal models (murine, non-human primate) and human samples.
  • Record work into Benchling electronic lab notebook (ELN) to maintain records.
  • Digitizing stained slides using Akoya Vectra imaging system and Keyence imaging system to quantify and analyze the results.
  • Generate, collect, analyze and presenting experimental data in team meetings as needed.
  • General maintenance of histology and microscopy lab by ordering needed reagents and supplies accordingly.
  • Work and manage multiple projects simultaneously.
  • Perform routine IHC staining using optimized protocols and analyzing the results for documentation and reporting.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.