Associate Scientist / Senior Associate Scientist, Preclinical Research

Generation Bio

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 05/12/2021
  • Website: generationbio.com
  • Company Address: 215 First Street, Cambridge, Cambridge, MA, MA 02142

About Generation Bio

Generation Bio is creating a revolutionary new class of genetic medicines that deliver durable, high levels of gene expression and have drug-like properties, including ability to titrate to effect and re-dose. Our unique GeneWave technology allows us to overcome the limitations of other approaches by delivering larger genes, including more sophisticated regulatory elements, and avoiding the immunogenicity which limits both the number of patients who can be treated and the ability to re-dose them over time.

Job Description

Generation Bio is an innovative genetic medicines company focused on creating a new class of non-viral gene therapy to provide durable, redosable treatments for people living with rare and prevalent diseases. The company’s non-viral platform incorporates a proprietary, high-capacity DNA construct called closed-ended DNA, or ceDNA; a cell-targeted lipid nanoparticle delivery system, or ctLNP; and an established, scalable capsid-free manufacturing process. The platform is designed to enable multi-year durability from a single dose of ceDNA and to allow titration and redosing if needed, and our scalable manufacturing process supports our mission to extend the reach of gene therapy to more people, living with more diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.

We are a thriving, collaborative, creative community of 120 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

Delve further. Please visit www.generationbio.com or follow @generationbio.

SUMMARY:

Generation Bio seeks an energetic, versatile, and highly motivated associate/sr. associate scientist to join our Preclinical Research group. For this lab-based position, the successful candidate will support our antibody gene therapy platform and preclinical development of our growing pipeline of development candidates. The ideal candidate will have a background in research and development of biologics with experience in their characterization and expression in vitro. This role will be primarily responsible for implementing biochemical and cell-based assays for antibody gene therapy therapeutic lead selection as well as supporting efforts to optimize recombinant antibody expression.

RESPONSIBILITIES:

    Carry out molecular and cell biology experiments, including but not limited to, DNA cloning, transient transfections, electrophoresis, cell culture maintenance
    Optimize and execute plate-based assays to assess expression (e.g. ELISA, RT-qPCR, Western Blot) & functional activity (e.g. target engagement, enzyme activity, signaling pathway activation/inhibition) from tissue samples, plasma/serum, and cell culture.
    Design experiments, analyze data & interpret results
    Summarize studies in written reports and oral presentations

REQUIREMENTS:

    B.S. or M.S. with 2+ years of relevant industry experience (preferred)
    Excellent lab technique and the ability to work independently to analyze, interpret, and present data
    Proficient in protein detection methods including ELISA, MSD, and Western Blot analysis from both in vivo (tissue/plasma/serum) and in vitro (cells) samples
    Proficient with cell culture manipulation techniques (e.g., transfections, cell-based assays)
    Experience running in vitro assays to assess binding affinity (e.g. Octet, Biacore) is a plus
    Experience with DNA/RNA purification and quantification, biochemical assays, enzymatic assays, and/or cell imaging methods (e.g. IHC, FACS) is a plus
    Ability to multi-task to support multiple projects across platform and disease biology pharmacology
    Ability to work in a highly collaborative, cross-functional environment
    Excellent written and verbal communication skills
    Prior experience with gene therapy and/or lead optimization a plus

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.