Scientist, Platform Development

Dyne Therapeutics

Waltham, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 04/29/2021
  • Website:
  • Company Address: 400 Technology Square 10th Floor, Cambridge, MA, 02139

About Dyne Therapeutics

Dyne was founded with a singular focus: to transform the lives of people with serious muscle diseases by pioneering muscle-targeted therapies. Our proprietary technologies provide the foundation for breakthrough treatments. We have assembled a world-class team of experts who are united by their commitment to fulfill this mission.

Job Description

Company Overview:

Dyne Therapeutics is building a leading muscle disease company dedicated to advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE™ platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue seen with other approaches. Dyne’s broad portfolio of therapeutic candidates for serious muscle diseases includes programs for myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit, and follow us on Twitter, LinkedIn and Facebook.

Role Summary:

Dyne is seeking a talented and highly motivated Scientist in biology/chemistry/biochemistry to help generate and advance our therapeutics research and support our drug discovery programs. This team member will collaborate closely with in vitro/in vivo biology colleagues to generate and characterize research materials and will also help establish and contribute to the operations of our laboratories.

The ideal candidate is a highly motivated individual with exceptional communication and collaboration skills. The qualified candidate will have the opportunity to build, contribute to, and expand our innovative platform technology and advance Dyne's mission of pioneering life-transforming therapies for patients with serious muscle diseases.

Primary Responsibilities Include:

    Execute research plans for the generation of research therapeutic candidates for in vitro and in vivo studies
    Analyze the stability, potency, efficacy and purity of therapeutic materials
    Develop in vitro systems for high-throughput screening of drug candidates
    Identify and validate novel therapeutic targets to expand our FORCE platform
    Contribute to critical discussions of therapeutic structure, activity, and function

 Education and Skills Requirements:

    MS/PhD in biology/chemistry/biochemistry and 2-5 years of hands-on industry experience in early drug discovery and development
    Experience in cell culture and in vitro cell-based assays (Flow Cytometry, Fluorescence Microscopy, ELISA, cell reporter systems)
    Experience with high-throughput screening of candidate biologics or small molecules
    Skills with chromatographic separation are a plus (e.g. SEC, HPLC, HIC, IEX, LC-MS)
    Strong organizational skills and attention to detail
    Ability to effectively communicate ideas and document research
    Experienced in software applications (Prism, Excel, PowerPoint)
    Must be authorized to work in the United States
    Position is based in Waltham, MA; no relocation package available

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.