Research Associate, Protein Sciences

Xilio Therapeutics

Waltham, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 04/21/2021
  • Website:
  • Company Address: 828 Winter Street, Waltham, MA, 02451

About Xilio Therapeutics

Xilio Therapeutics is a biopharmaceutical company focused on developing highly-potent, targeted immuno-oncology therapeutics.

Job Description

Xilio Therapeutics is a development-stage biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. The company’s tumor-selective immunotherapies are based on its proprietary technology, which maximizes the potency of modulating key pathways in immune-oncology and restricts their activity to the tumor to minimize peripheral side effects. The broad applicability of these therapies across cancer types means that all patients could benefit from these potentially curative medicines.

Xilio was founded in 2016 and closed a $95M Series C financing from blue chip venture investors in February 2021. Xilio is headquartered in Waltham, MA.


We are looking for a Research Associate to join our Protein Sciences group in Biologics Department. The efficient, high-quality production of therapeutic proteins is a critical component of our research platform. We seek an individual excited about contributing directly through mammalian expression and purification of therapeutic proteins and helping to maintain our protein inventory. This position will interact closely with the rest of the Protein Production Team, as well as Molecular Biology and Bioanalytics within a dynamic, enthusiastic, highly interdisciplinary and collaborative team.


    Perform mammalian cell culturing and cryopreservation.
    Express engineered fusion proteins via transient expression in HEK and CHO cells.
    Purify proteins using chromatography tools including preparative FPLC.
    Perform a variety of characterizations on protein samples, including SDS-PAGE, analytical SEC, concentration and endotoxin measurements.
    Compile QC reports with data from cross-functional teams and prepare COAs.
    Track sample requests, aliquot, and deliver samples to internal teams and external partners.
    Enter all data into laboratory notebooks and databases and generate weekly summary reports.
    Regularly participate in and present data and analyses at protein production team meetings and department meetings.


    BS/BA degree with 0-3 years of experience in a protein purification lab. Additional consideration will be given to those with experience working in a biotechnology or pharmaceutical company.
    Experience with protein expression and/or purification is preferred.


    Excellent organization skills and attention to detail is essential.
    Familiarity using a LIMS system or a scientific database is a plus.
    Works well in a cross functional team environment.
    Good verbal and written communication skills.
    Driven by a desire to create the next generation of immunotherapy-based cancer therapeutics and the vision to offer cancer patients efficacious and tolerable new therapies that extend and improve their lives.

Xilio offers the opportunity to work in an innovation driven, exciting biotechnology company doing ground-breaking work in the field of immuno-oncology. We offer a competitive compensation package including a base salary, annual bonus potential, stock options, 401k, healthcare benefits and paid time-off.

POSITION: Full-Time, Exempt

EEOC Statement: Xilio Therapeutics believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Xilio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.