Principal Scientist, Platform Medicinal Chemistry

Kymera Therapeutics

Watertown, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 04/29/2021
  • Website:
  • Company Address: 400 Technology Square, 10Th Floor, Cambridge, MA, 02139

About Kymera Therapeutics

Kymera Therapeutics is a biotechnology company pioneering a transformative new approach to treating previously untreatable diseases. The company is advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade rather than inhibit dysregulated, disease-causing proteins. Powered by a proprietary predictive modeling capability and a game-changing integrated degradation platform, Kymera is accelerating drug discovery with an unmatched ability to target and degrade the most intractable of proteins, and advance new treatment options for patients.

Job Description

We are seeking an experienced medicinal chemist to drive chemistry efforts for the identification of novel E3 ligase ligands and the development of innovative heterobifunctional E3-POI degraders for cellular proof-of-concept studies, with the aim of advancement to pipeline programs for the identification of clinical drug candidates. This scientist should have a track record of medicinal chemistry accomplishments resulting in high impact on lead generation campaigns and drug discovery programs. This is a non-laboratory based role may include chemistry team leadership and project team leadership.

Kymera Therapeutics is a clinical stage biotechnology company focused on advancing the field of targeted protein degradation (TPD), a transformative new approach to address previously intractable disease targets. Kymera’s Pegasus™ TPD platform harnesses the body’s natural protein recycling machinery to degrade disease-causing proteins, with a focus on undrugged nodes in validated pathways currently inaccessible with conventional therapeutics. Our mission is to discover, develop, and commercialize transformative therapies while leading the evolution of targeted protein degradation. Kymera’s goal is to become a fully integrated biopharmaceutical company with a pipeline of novel medicines, with an initial focus on immune-inflammatory diseases and oncology.

In 2021, we plan to continue to grow and strengthen our organizational capabilities to deliver on the potential of inventing a new class of protein degrader medicines for patients. Kymera is rapidly advancing three programs in clinical studies this year. We are also actively advancing a broad pipeline of preclinical programs across a wide variety of diseases, both internally and in collaboration with our partners Sanofi and Vertex Pharmaceuticals.


    Leverage a strategic and holistic approach to hit identification and lead generation, including the use of fragment-based drug discovery and ligand-, property-, and structure-based drug design.
    Drive state-of-the-art multiparameter optimization with creativity, innovation, in-depth analysis of data, and existing literature information.
    Meaningfully impact molecular design and synthetic route identification for all Platform projects.
    Exhibit effective leadership and management of CRO chemistry teams through excellent synthetic and medicinal chemistry skills with clear and open communication.


    PhD in organic chemistry with 6+ years of experience as a medicinal chemist in the biotechnology or pharmaceutical industry.
    Demonstrated knowledge of key molecular recognition, ADME, biochemical, pharmacological and safety principles and application of this knowledge to the design of new molecules.
    Excellent synthetic organic chemistry skills and creativity are required.

Personal Attributes:

    Strong sense of urgency to help bring new and more effective medicine to patients.
    Goal-oriented, with the ability to operate in a fast-paced environment and a highly collaborative, data-driven, creative mindset.
    Excellent verbal and written communication skills.

Kymera Therapeutics is an equal opportunity employer and welcomes all job applicants. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.