Senior Research Associate, AAV Capsid Engineering

Shape Therapeutics

Seattle, WA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 04/28/2021
  • Website: www.shapetx.com
  • Company Address: 500 Yale Ave N, 3rd floor, Seattle, Washington, 98109, US

About Shape Therapeutics

Shape Therapeutics (ShapeTx) is a development-stage biotechnology company establishing itself as the leader in next-generation gene therapy. Our novel technology platform enables direct in vivo targeting/modification of RNA by leveraging ADARs (Adenosine Deaminase Acting on RNA), suppressor tRNAs, and immune-stealth adeno-associated viruses (AAVs).

ShapeTx is providing solutions to many of the challenges that contemporary genome engineering technologies face (like CRISPR, TALENs, etc.), such as permanent off-target damage, high risk of immunogenicity and therefore low in vivo applicability as effective gene therapy approaches. ShapeTx’s technology instead engages natural human cellular machinery to target RNA with high in vivo efficiency.

Shape Genome, Shape Life!

Job Description

Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies. 

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.


ShapeTX is looking for a highly motivated and rigorous scientist with expertise in molecular biology, high-throughput screening, next generation sequencing and cell culture to join the Delivery Sciences team as a Senior Research Associate, AAV Capsid Engineering. In this role, the successful candidate will design, build, and apply novel AAV capsid screening tools to further extend ShapeTX’s cutting-edge AAVidTM technology platform. This role will also contribute to the characterization of lead capsid variants and facilitate their translation into gene therapies. The ideal candidate will have broad technical skills in molecular biology, DNA/RNA isolation, vector design, cell culture, virology, high-throughput screening and/or next generation sequencing. A collaborative spirit and a passion to rigorously develop novel technologies are critical to succeed in this role. 

Roles and Responsibilities:

  • Design and execute well-controlled experiments
  • Optimize and apply cutting-edge, extensible, and scalable AAV capsid screening platforms
  • Develop and utilize quantitative next-generation DNA and RNA sequencing assays
  • Analyze data promptly to clearly depict and communicate results
  • Maintain a detailed and up-to-date electronic laboratory notebook
  • Maintain detailed organization systems for samples and reagents from complex experimental pipelines

Requirements:

Preferred Qualifications:

  • Bachelor's or Master's Degree in Molecular Biology, Virology, Genomics or a related discipline
  • Demonstrated scientific rigor through peer-reviewed publications or documented contributions to technology development teams
  • 4+ years of experience in an academic or industry setting
  • Ability to work both independently and collaboratively in a team-science environment
  • Ability to think outside the box and tackle challenges with a problem-solving, can-do attitude

Skills and Experience:

  • Experience with molecular biology techniques and analysis (construct design, library cloning, DNA/RNA purification, Sanger sequencing, qPCR, ddPCR, NGS library prep, RNA-seq, etc.)
  • Experience with cell-culture, virology and related methods (virus preparation, ELISA, flow cytometry, etc.)
  • Experience with AAV, high-throughput screening systems, and/or bicistronic viral vector design a plus
  • Ability to troubleshoot and think analytically
  • Stellar work ethic and a passion for benchwork
  • A collaborative, team player and good lab citizen
  • Exquisite attention to detail and organization
  • Effective and proactive written and verbal communication
  • Ability to multitask and support multiple projects simultaneously

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.