Associate Director, AAV Process Development

CRISPR Therapeutics

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Manufacturing
  • Post Date: 04/02/2021
  • Website: crisprtx.com
  • Company Address: 610 Main Street, Cambridge, MA, 02139

About CRISPR Therapeutics

CRISPR Therapeutics is a leading gene-editing company focused on the development of transformative medicines using its proprietary CRISPR/Cas9 gene-editing platform.

Job Description

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom.

Job Summary

This is a highly visible position that will require a person with a diverse set of skills who functions well in a fast-paced environment.  The focus of this individual will be in Upstream Process Development of AAV. Our ideal candidate will have hands-on technical experience developing and characterizing manufacturing processes for engineered gene therapy products and will be a dedicated people leader capable of getting the best out of those around her/him  If you possess these qualities, like a challenge, love to learn and want to be part of a team developing the next generation of cell and gene therapeutics based on CRISPR/Cas9, we want to hear from you.

Responsibilities

  • Lead a team of highly productive cell culture scientists and engineers.  Identify and develop future technical leaders.
  • Develop scalable processes to produce novel AAV-based therapies with a creative eye to accelerating new products into the clinic.
  • Design, perform and evaluate experiments to develop robust unit operations using DoE, multivariate analysis, and other statistical tools.
  • Build a science-based understanding of the product/process to define critical process parameters (CPPs) and establish acceptance criteria. 
  • Identify, develop, and optimize novel AAV production platforms.
  • Manufacture critical materials for developmental and preclinical testing and participate in/present to cross functional teams.
  • Participate in technology transfer activities with CMOs and build strong relationships with collaborating companies.

Minimum Qualifications

  • MS (10+ years industry experience) or PhD (7+ years industry experience) in a relevant scientific discipline (e.g. Biological or Chemical Engineering, Biology, Immunology, Virology).
  • Bioprocess development experience with at least 3 years of experience managing process development teams.
  • Demonstrated, hands-on expertise developing upstream processes in shake flasks, bench-scale stirred-tank and rocking bioreactors and pilot-scale (50L+) bioreactors.
  • Strong awareness of the literature, technologies, and industrial landscape of AAV process development.  
  • Knowledge of practices and equipment in a GMP manufacturing environment, including closed-systems, single-use/disposable technology, and sterile/aseptic processing. 
  • Application of advanced automation and statistical data analysis in development, including DoE.
  • Desire to take on new technology challenges and broaden technical skill set.
  • Excellent verbal and written communication skills.
  • Ability to work effectively in a highly cross functional team-oriented environment; driven and highly organized. 
  • Ability to influence people and achieve win-win outcomes.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.