Research Associate II /Associate Scientist I, Translational and Exploratory Biology (TEB)

Acceleron Pharma

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 04/01/2021
  • Website: acceleronpharma.com
  • Company Address: 128 Sidney Street, Cambridge, MA, 02139

About Acceleron Pharma

Acceleron is a biopharmaceutical company dedicated to the discovery, development, and commercialization of therapeutics to treat serious and rare diseases. The Company's leadership in the understanding of TGF-beta superfamily biology and protein engineering generates innovative compounds that engage the body's ability to regulate cellular growth and repair.

Job Description

We are seeking a highly motivated individual to be part of our dynamic and collaborative  TEB group. The focus of this laboratory-based role will be to provide support with  in-vitro and in vivo assays as well as ex-vivo analysis including primary cell and tissue cultures. The successful candidate will join a dynamic group of scientists working on integrated aspects of TGFb superfamily and learn new cutting-edge techniques/technologies and apply them to various disease indications mentioned above. There is immense growth potential for those seeking an industry  career.

 

What will you be doing?

  • Supporting different projects in their preclinical/translational studies with end point analyses
  • Carrying out ex vivo study such as precision-cut tissue slicing of rodent or human tissues and running in vitro culture and treatment for disease progression monitoring as well as drug-intervention and efficacy evaluation  
  • Participating in various mechanism of action studies to elucidate the drug action by performing various cellular, nucleic acid and protein-based techniques and evaluating the outcome of those studies. Examples include:
    • RNA isolation and qRTPCR analyses
    • Quantitative western blotting techniques
    • Plate-based assays such as ELISA, luciferase/fluorescence/chromogenic measurements
    • Coordinating/collaborating with IHC core facility in performing immuno histochemistry as well as RNA in situ hybridization on various tissue slices to look for gene expression and biomarkers
  • Working with cross-functional drug development groups to help bring research stage molecules to clinical development
  • Preparing, presenting and reviewing scientific presentations for internal/external use; Maintaining human and animal primary cell and precision cut tissue cultures, drug treatments and performing end point analyses

 

What are we looking for?

  • BS degree with 3+ years of academic or industrial experience in a few different disease models or translational research
  • Should have experience working with cell cultures and basic transfection procedures using plasmid DNA and siRNA etc. Working knowledge in tissue culture, organotypic or 3D culture models would be an asset but not required
  • Experience in performing routine lab techniques such as nucleic acid isolation, setting up PCR/qRTPCR, data analyses, western blots, and basic imaging techniques like immunofluorescence/confocal microscopy
  • Experience in handling mice and/or other lab rodents as well as knowledge/experience of common dosing approaches
  • Quantitation of imaging and western data using software such as ImageJ, Halo, Imaris or Zen Blue is preferable.

How will you grow with us?

You will have an exciting opportunity as a member of our TEB   group to significantly contribute to our exciting  programs at different stages.  We are expanding our translational function and you will be a key member in the execution of the group’s activities.  This opportunity will allow you to work with passionate team members who are dedicated to our innovative science; you will have a great learning and growth opportunity for your career in biotech/pharmaceutical industry.  

*In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and complete the required employment eligibility verification document form upon hire.

*Recruiters - please do not send unsolicited resumes to this posting.

FOR IMMEDIATE CONSIDERATION PLEASE VISIT OUR WEBSITE AT:

www.acceleronpharma.com

Acceleron is a biopharmaceutical company dedicated to the discovery, development, and commercialization of therapeutics to treat serious and rare diseases. Acceleron’s leadership in the understanding of TGF-beta superfamily biology and protein engineering generates innovative compounds that engage the body's ability to regulate cellular growth and repair. Acceleron focuses its research, development, and commercialization efforts in pulmonary and hematologic diseases. In pulmonary, Acceleron is developing sotatercept for the treatment of pulmonary arterial hypertension (PAH), having reported positive topline results of the PULSAR Phase 2 trial. The Company is currently planning multiple Phase 3 trials with the potential to support its long-term vision of establishing sotatercept as a backbone therapy for patients with PAH at all stages of the disease. Acceleron is also investigating the potential of its early-stage pulmonary candidate, ACE-1334, which it plans to advance into a Phase 1b/2 trial in systemic sclerosis-associated interstitial lung disease (SSc-ILD) next year. In hematology, REBLOZYL® (luspatercept-aamt) is the first and only erythroid maturation agent approved in the United States, Europe, and Canada for the treatment of anemia in certain blood disorders. REBLOZYL is part of a global collaboration partnership with Bristol Myers Squibb. The Companies co-promote REBLOZYL in the United States and are also developing luspatercept for the treatment of anemia in patient populations of myelodysplastic syndromes, beta-thalassemia, and myelofibrosis. For more information, please visit www.acceleronpharma.com. Follow Acceleron on Social Media: @AcceleronPharma and LinkedIn.

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