Scientist I / Sr. Scientist, Nano-immunotherapy


Gaithersburg, MD, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 03/26/2021
  • Website:
  • Company Address: 22 Firstfield Road Suite 280, Gaithersburg, MD, 20878

About NexImmune

NexImmune is an emerging biopharmaceutical company advancing a new generation of immunotherapies based on our proprietary AIMâ„¢ technology.

Job Description

NexImmune is a clinical-stage biotechnology company developing a novel approach to immunotherapy designed to employ the body’s own T cells to generate a specific, potent, and durable immune response that mimics natural biology. We are seeking highly skilled and motivated individuals to join an entrepreneurial team of experienced professionals dedicated to science, patients and addressing diseases with significant unmet need. We are a company with an uncompromising commitment to shared values, a strong work ethic, and respect for individuals. We set clear expectations, empower people to succeed, and reward results. Our executive team, Board of Directors, and investors include several successful industry veterans committed to building an exceptional company capable of transforming the field of immunotherapy.

The backbone of NexImmune’s approach is its proprietary Artificial Immune Modulation (AIMTM) nanoparticle technology platform. The AIM technology enables NexImmune to construct nanoparticles that function as synthetic dendritic cells capable of directing a specific T cell-mediated immune response. By mimicking natural T cell biology, NexImmune’s T cell product candidates are designed to combine the attributes of cellular precision, potency, and persistence with reduced potential for undesired toxicities.

NexImmune’s two lead programs, NEXI-001 and NEXI-002, are in Phase 1/2 clinical trials for the treatment of relapsed AML after allogeneic stem cell transplantation and multiple myeloma refractory to at least 3 prior lines of therapy, respectively. NexImmune is also developing new AIM nanoparticle constructs and modalities for potential clinical evaluation in oncology and in disease areas outside of oncology, including autoimmune disorders and infectious disease.
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Position Summary:

The Scientist I / Senior Scientist in preclinical nano-immunotherapy will act as a scientific contributor for developing and optimizing a new clinical approach to treat autoimmune diseases, based upon NexImmune’s proprietary artificial Antigen Presenting Cell (aAPC) technologies. The candidate will assist in the formulation of nanoparticle-based aAPC, characterization and functional assessment of aAPC and antigen-specific T cells. Laboratory skills, notebook recording/maintenance, and writing of reports in acceptable scientific format(s) are important. He/she will be involved in data analysis and interpretation, writing and implementing SOPs, and helping with other work as required by the company, thereby working closely with multiple teams.

Essential Duties and Responsibilities:

  • Provide support for nanoparticle development for broad clinical applications
  • Perform cell culture of mammalian and animal cell line
  • Isolation and expansion of antigen-specific T cells
  • FACS analysis
  • Perform ELISA, protein assays, cell-based assays, and nanoparticle-based assays
  • Assay development and validation
  • Write reports, protocols, SOPs. Prepare data summaries and presentations.
  • Order supplies and reagents, maintain inventory records

Education and Experience:

  • MS or PhD in Life science (Immunology, Biology, Biochemistry or related field)
  • Experience in immunology, T cell biology, autoimmune biology
  • Experience with mammalian and animal cell culture, sterile techniques
  • Experience with FACS, panel design, and FlowJo
  • Experience with ELISA, protein assays, and other plate reader-based assays
  • Experience with mouse models for autoimmune diseases
  • Experience in writing data summaries and preparing scientific presentations
  • Demonstrated proficiency in GraphPad Prism, MS Office including Word, Excel and PowerPoint

Desired Key Competencies:

  • Hands-on experience and knowledge of FACS, ELISA and cell culture techniques
  • Self-motivated, independently minded, responsive with can-do attitude
  • Positive interpersonal skills with the ability to interact with individuals from a variety of levels/functions
  • Self-organizer, meticulous hands-on habits, keen attention to detail
  • Strong quantitative and analytical skills
  • Can coordinate parallel tasks across multiple projects, demonstrating prioritization
  • Ability to quickly adapt to a rapidly changing environment and demands
  • Ability to interpret and effectively execute upon a variety of instructions provided in written, oral, diagram or schedule formats.

Qualified, interested candidates should send a resume to: [email protected]

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.