Senior / Research Associate, Cancer Biology

Relay Therapeutics

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 04/01/2021
  • Website: relaytx.com
  • Company Address: 399 Binney Street, 2nd Floor, Cambridge, MA, 02139, US

About Relay Therapeutics

Relay Therapeutics is a new breed of company at the intersection of computation and biotechnology that is committed to creating medicines that will have a transformative impact on patients. Relay Therapeutics’ approach combines unprecedented computational power with leading-edge experimental approaches across the fields of structural biology, biophysics, chemistry and biology. This integration illuminates – for the first time – the full mobility of a protein and provides key insights into how the dynamic nature of a protein’s conformation regulates function. By applying these insights, Relay Therapeutics aims to modulate protein conformation to develop novel therapies for patients. Headquartered in Cambridge, Massachusetts, Relay Therapeutics is a private company launched in 2016. To date the company has raised $520M from investors including Third Rock Ventures, SoftBank Vision Fund, GV, Casdin Capital, BVF Partners, EcoR1 Capital, Foresite Capital, Perceptive Advisors, Tavistock Group and an affiliate of D.E. Shaw Research.

Job Description

We are seeking a self-motivated researcher who is excited to join a dynamic and collaborative team of scientists driving the discovery of novel small molecule therapeutics in oncology.
In this role, you will design and execute molecular and cellular biology experiments focused on evaluation of candidate molecules, and development of novel biomarkers. You will interact and collaborate cross-functionally with scientists in other departments, including biochemists, chemists, and computational biologists while growing your understanding of drug discovery and helping bring medicines to patients. 

Your Role:

    • Design and perform cell and molecular biology experiments to support the biological evaluation of small molecules impacting cancer dependencies
    • Develop, optimize and conduct cell-based assays (target engagement, cell proliferation, cell cycle, reporter-based) to enable medicinal chemistry efforts and structure activity relationship assessment
    • Develop and perform target engagement assays from tumor samples from xenograft and PDX models
    • Maintain good written records of laboratory procedures, results and conclusions
    • Analyze data carefully and report findings to the team
    • Collaborate with CROs for any outsourcing needs and integrate data analysis
    • Present your work at regular department and company meetings

Your Background:

    • BS/MS with 3+ years of industry/academic experience working in a cancer biology team is desirable
    • Experience in molecular biology (nucleic acid purification, DNA cloning, PCR, gel electrophoresis, Western blotting, and qPCR, si/shRNA, CRISPR, lentiviral gene knockdown)
    • Exceptional cell biology capabilities (experience with solid and suspension mammalian cells, flow cytometry, microscopy).  
    • Ability to design and execute experiments, analyze and document results
    • Excellent organizational and communication skills
    • Excellent problem-solving skills and ability to multi-task
We believe in building balanced teams and a place where our people can be their best self every day. We encourage people from underrepresented backgrounds to apply. 
 
Relay Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
 
Our Culture:
At Relay Tx, we believe that along with our people, our culture is our greatest asset.  In fact we're proud to share we were named as one of the Boston Business Journal's "Best Places to Work" in 2017, the #1 place for small companies in 2018 & the #2 place for small companies in 2019. To drive that culture, no one will stop you or hold you back. Instead, we will give you the tools and colleagues to push forward relentlessly and cheer you on as you go. If this resonates with you, drop us a line.
 
About Relay Therapeutics
Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology and genetic diseases. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process.
 
Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you’re excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us!

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.