Downstream Process Development, Supervisor

Curie Co

Durham, NC, US
  • Job Type: Full-Time
  • Function: Manufacturing
  • Post Date: 04/03/2021
  • Website: curieco.com
  • Company Address: 101 Ave of the Americas Lab 307-A, New York, NY, 10013

About Curie Co

Curie Co is a life science company that engineers enzymes and marine biomaterials to replace harmful and banned chemicals.

Job Description

Curie Co uses the power of biotechnology to replace petrochemicals in everyday products, with more sustainable, engineered enzymes. We’re looking for team members passionate about achieving this mission and contributing to the biomanufacturing revolution. Individuals with exceptional multitasking skills, attention to detail, and self-motivated with the ability to work independently and thrive in a fast-paced environment. Excellent relational, communication, and presentation skills are highly regarded to help continue to foster a collaborative and learning environment.
 
 
 

Main Responsibilities:

    • Develop commercially scalable processes for the purification of recombinant proteins and enzymes expressed in microbial hosts (e.g., bacteria or yeast)
    • Implement and execute the purification of recombinant proteins
    • Participate and advise in the development of final product specifications
    • Support development of unit operations at the bench -scale (10-20L) such as, centrifugation, homogenization, crystallization, ultra-filtration, depth filtration, ion exchange and preparative chromatography
    • Collaboratively design and execute experiments (DOE), analyze data, write and review technical reports and protocols, and present during team meetings
    • Prepare technology transfer documents including detailed process descriptions, mass balances, process flow diagrams (PFD’s)
    • Research, learn, and incorporate promising techniques and technologies in protein purification

Qualifications:

    • Degree in Biochemistry, Chemical Engineering or related discipline w/5+ years of industrial biotech experience
    • Sound understanding of protein biochemistry and recombinant protein expression in microbial hosts relevant to downstream purification
    • Strong technical background and direct hands-on experience with large scale protein purification downstream processing unit operations such as preparative chromatography, centrifugation, homogenization, micro filtration, ultra-filtration, etc. 

Preferred Qualifications:

    • Proficiency is a plus: ammonium sulfate precipitation, or purification from bacterial inclusion bodies
    • Proficiency is a plus: protein purification using affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography
    • Technoeconomic analysis
    • Experience with final formulation, granulation, spray drying is a plus

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.