Associate / Senior Associate Scientist, Drug Product Formulation-CMC

Generation Bio

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Manufacturing
  • Post Date: 04/01/2021
  • Website: generationbio.com
  • Company Address: 215 First Street, Cambridge, Cambridge, MA, MA 02142

About Generation Bio

Generation Bio is creating a revolutionary new class of genetic medicines that deliver durable, high levels of gene expression and have drug-like properties, including ability to titrate to effect and re-dose. Our unique GeneWave technology allows us to overcome the limitations of other approaches by delivering larger genes, including more sophisticated regulatory elements, and avoiding the immunogenicity which limits both the number of patients who can be treated and the ability to re-dose them over time.

Job Description

Description

 

Generation Bio is a biotechnology company leading a new generation of gene therapy. With our proprietary re-dosable ceDNA technology, we are expanding the reach of gene therapy. At Generation Bio, our goal is to bring the life-saving benefits of gene therapy to more people, living with a broader range of diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.

We are a thriving, collaborative, creative community of diverse talents, beliefs, and experiences relentlessly dedicated to our mission. Founded and launched by Atlas Venture. Headquartered in Cambridge, Massachusetts. Committed to a future where more people can live full lives.

Delve further. Please visit www.generationbio.com or follow @generationbio.

SUMMARY

Generation Bio seeks an energetic and highly driven hands on Scientist to conduct manufacturing and process development operations for drug product formulations using lipid nanoparticle platforms. The successful candidate will be an integral part of a cross functional team optimizing novel approaches for delivery for our gene therapy platform.

RESPONSIBILITIES:

  • Design and execute experiments to optimize the Drug Product manufacturing process using both DNA vectors and lipid nanoparticles (LNPs).
  • Support the production and analytical characterization of LNP formulations targeted for research and pre-clinical programs.
  • Collaborate with R&D to aid in the development and evaluation of LNP formulations for product delivery.
  • Help support external, technical interfaces to contract manufacturing organizations.
  • Maintain thorough electronic lab notebooks and ensure completion of all appropriate protocols and documentation.
  • Communicate findings internally and present results broadly in cross-functional meetings.

QUALIFICATIONS:

  • Minimum of B.S. with 2+ years experience or M.S. with 0+ years experience in the pharmaceutical industry. Degree in Chemical Engineering, Pharmaceutics, Materials Science, Polymer Chemistry, Chemistry, Biochemistry, or related field.
  • Experience in formulation and process development of nanoparticles for drug delivery. Specific experience with lipid nanoparticles is preferred.
  • Familiarity with process engineering principles and Design of Experiment (DOE) statistical tools.
  • Experience working with cross-functional teams including research and development, pre-clinical, manufacturing operations, and quality control.
  • Demonstrated ability to operate in a fast-paced environment.
  • Excellent communication, interpersonal and organizational skills.
  • Results-driven with excellent attention to details.
  • Proven ability to effectively plan and organize complex work activities and prioritize task completion to meet schedules and deadlines.

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.