Principal Scientist, Clinical Translational Sciences


Abingdon, GB / Oxfordshire, GB
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 04/30/2021
  • Website:
  • Company Address: 351 Rouse Boulevard , Philadelphia, PA , 19112

About Adaptimmune

Adaptimmune, a leader in T-cell therapy, is a multinational, clinical-stage biopharmaceutical company focused on developing novel immunotherapies using its proprietary SPEAR T-cell receptor platform to treat solid tumors, which has the potential to transform the treatment of cancer.

Job Description

This is a senior role in the Translational Sciences team which functions out of both our UK and USA sites, providing broad translational sciences support to Adaptimmune’s clinical programs, and to the research teams.   The Translational Sciences team remit is to support exploration of the mechanism of action of Adaptimmune’s cell therapy products, providing a better understanding of the drivers of safety, efficacy and durability, and guiding identification of biomarkers of response and indication selection.  The team also provides valuable insights into tumor immune evasion mechanisms, guiding development of next generation products and provides support to pre-clinical research programs.

The candidate will work collaboratively with diverse functional groups within Adaptimmune and across external partnerships to accomplish translational science objectives. The primary responsibility will be to act as the translational sciences representative for early and late development clinical teams as required. This will involve helping to set and execute on translational strategy, analysing, collating and communicating data to multiple stakeholders and following up on learnings. The candidate will also participate in authoring relevant sections pertaining to translational science/ correlative studies in documentation for regulatory submissions to governmental regulatory agencies and will contribute to external publications. 

• Participate in clinical project teams as the translational sciences representative, taking responsibility for delivering on translational project strategy.   
• Manage, collate, analyse, interpret and communicate high quality translational data to multiple stakeholders in a timely fashion.
• Follow up on translational learnings across all stakeholders and feed back into research.
• Provide relevant sections for regulatory documents. 
• Contribute to clinical protocols as the translational sciences expert.
• Manage or contribute to external partnerships as required.
• Represent the company at conferences and scientific meetings externally, making presentations and preparing publications.  
• Stay abreast of the literature in immune cell therapy and clinical biomarkers and communicate internally.
• Develop good scientific relationships with Investigators and clinical site personnel, presenting data and ensuring good communication.
• Communicate strategy and progress to senior management at governance meetings.


• PhD or MD/PhD in immunology, cell therapy for cancer or a related field.
• Experience in clinical translational sciences in the immuno-oncology field. 
• Experience in clinical research, with good understanding of the collection, handling and processing of tumor specimens, blood and other clinical samples in a biotech/pharmaceutical industry, academic, or CRO environment is strongly preferred.
• Experience in adoptive cell therapy for cancer in a biotech or pharma environment.
• Proven leadership experience.


• Strong credible leadership skills within Project teams.
• Excellent scientific knowledge and drive. 
• Ability to make sound and timely strategic decisions, prioritise, plan projects and deliver to timelines. 
• Strong team player with ability to work in cross-functional teams and a highly matrixed environment. 
• Excellent communication skills (both written and verbal).
• High attention to detail, good time management skills. 
• Excellent numeracy and English language skills (both written and verbal).
• Proven project management skills.
• Computer literate and ability to familiarise with different IT systems.

At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.