Principal Scientist – Discovery Biology

Nurix

San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 02/22/2021
  • Website: nurix-inc.com
  • Company Address: 1700 Owens Street Suite 500, San Francisco, CA, 94158

About Nurix

Nurix Therapeutics discovers drugs that harness the body's natural process to control protein levels.

Our drugs control ubiquitin E3 ligases, the key enzymes responsible for protein breakdown in human cells, as a unique therapeutic approach to treat a broad range of diseases.

Our focus is on developing drugs to treat cancer including novel, small molecule immuno-oncology agents.

Job Description

We are seeking a highly skilled and motivated cell biologist/immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The senior scientist/associate director is an experienced immunologist that will perform and oversee lead optimization of novel compounds and the characterization of their MOA on immune cells. The candidate must be self-driven, organized, able to manage junior scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • D. in immunology or cancer biology with 8+ years of relevant industry experience.
  • Research experience in the field of immunology with a focus on either inflammation and autoimmunity, or immunoncology.
  • Strong background in small molecule drug discovery and lead optimization of molecules; experience with bi-functional degrader compounds is a plus.
  • Demonstrated experience in leading small team of scientists.
  • Ability to manage multiple projects simultaneously
  • Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells, ELISA, Western and multiplexing technologies
  • Excellent written and verbal communication skills across cross-functional teams
  • Background in ubiquitin biology with past experience is a plus
  • Ideal candidate can develop novel ideas/technologies and is eager to learn, innovate

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.