Senior Scientist, Group Lead - Cancer Biology - Platform Development

Monte Rosa Therapeutics

Basel, CH
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 02/20/2021
  • Website: monterosatx.com
  • Company Address: 40 Guest St, Boston, MA, 02135

About Monte Rosa Therapeutics

Monte Rosa Therapeutics is a biotechnology company developing molecular glues to degrade disease-causing proteins by creating a platform that designs small molecules that reprogram ubiquitin ligases to eliminate disease drivers previously deemed undruggable.

Job Description

We are seeking an energetic, experienced, and self-motivated PhD scientist to join a team of scientists working towards discovery of unique anti-cancer drugs for the treatment of targeted patient populations. The candidate will be a highly creative cancer biologist with a strong desire to succeed at the highest level. This individual will lead drug discovery projects in a team environment and direct the activities of research associates under their supervision.

 

Duties
  • Independently design, execute and interpret cell-based experiments to optimize compound selection and explore therapeutic potential of drug targets.
  • Lead drug discovery biology efforts to selection of lead candidate molecules and transition into clinical development
  • Design and develop cell and molecular assays to define mechanism of action for compounds, identify pharmacodynamic assays for utility in pre-clinical and clinical setting and test patient selection strategies
  • Utilize literature and internal genomics data sets to design and test hypothesis for drug targets
  • Interpret, present and report research findings at internal meeting an external scientific conferences
  • Manage and direct the activities of a group of research associates
  • Design strategies for cloning fusion reporter gene vectors, identify CROs to perform cloning and manage execution of the work.
  • Generated and maintain reporter cell lines
  • Perform viability assays, western blotting, and/or flow cytometry/FACS to analyze effect of small molecules on reporter expression
  • Validation of hits from high-throughput screens using medium-throughput plate based cellular assays, and high content cellular imaging assays. Strong understanding and hands-on experience with high content microscopy
  • Capability to develop, run and troubleshoot new assays in a high-throughput environment

Requirements

  • Ph.D equivalent in cell/molecular biology, Cancer Biology or genetics with >3 years industrial experience or MS with 10+ years of experience
  • Previous history of drug discovery with in Cancer Biology or Immunology application
  • Experience with state of the art molecular biology methods and assays essential to drive projects such as transfection and transduction techniques and working with pooled cDNA or shRNA libraries
  • Proven track record for striving for high level of innovation and scientific excellence
  • Excellent management, training and education skills
  • Excellent interpersonal skills with a proven record of empowering world class science and energizing teams
  • Flexibility to accommodate to rapidly changing priorities and deadlines
  • Ability to work in a team-based environment
  • Excellent oral and written communication skills

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.