Associate Scientist / Sr Associate Scientist, Downstream Process Development

Generation Bio

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 04/07/2021
  • Website: generationbio.com
  • Company Address: 215 First Street, Cambridge, Cambridge, MA, MA 02142

About Generation Bio

Generation Bio is creating a revolutionary new class of genetic medicines that deliver durable, high levels of gene expression and have drug-like properties, including ability to titrate to effect and re-dose. Our unique GeneWave technology allows us to overcome the limitations of other approaches by delivering larger genes, including more sophisticated regulatory elements, and avoiding the immunogenicity which limits both the number of patients who can be treated and the ability to re-dose them over time.

Job Description

Generation Bio is a biotechnology company leading a new generation of gene therapy. With our proprietary re-dosable ceDNA technology, we are expanding the reach of gene therapy. At Generation Bio, our goal is to bring the life-saving benefits of gene therapy to more people, living with a broader range of diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.

We are a thriving, collaborative, creative community of diverse talents, beliefs, and experiences relentlessly dedicated to our mission. Founded and launched by Atlas Venture. Headquartered in Cambridge, Massachusetts. Committed to a future where more people can live full lives.

Delve further. Please visit www.generationbio.com or follow @generationbio.

SUMMARY

Generation Bio seeks an enthusiastic and highly motivated scientist, to help with the development of downstream processes for production of our novel gene therapy product. The successful candidate will have good laboratory skills and attention to detail to help develop and optimize scalable purification processes for closed-ended DNA (ceDNA). The candidate will report to the Head of Downstream Process Development within the CMC group. This role will be integral to the success of the company as we advance clinical development candidates.

RESPONSIBILITIES:

Primary responsibilities for this role include:

  • Under guidance, design and execute laboratory experiments to develop downstream process for the purification of closed ended DNAs
  • Execute experiments and collaborate efforts related to the development of downstream process steps including cell lysis, depth filtration, TFF, and chromatography steps
  • Analyze process intermediates and final samples from the experiments
  • Assist in tech transfer of small-scale process to the in-house production group and to contract manufacturing organization (CMO) for scale-up
  • Assist in generating protocols, SOPs, and batch records
  • Keep good records and updated electronic notebook for all executed experiments.
  • Prepare, analyze, and present data internally to cross functional teams.

QUALIFICATIONS

  • BS in Biochemistry, Bioengineering, Biotechnology, or related discipline
  • Minimum 3-5 years of relevant industry experience
  • Experience in working with an oligonucleotide-based purification process is a plus
  • Result-driven with excellent attention to details
  • Ability to perform multiple experiments and responsibilities simultaneously
  • Ability to work with others to troubleshoot complex technical and scientific problems while showing independence in execution
  • Ability to adapt to a fast-paced organization

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.