Bioinformatics Engineer

Color

Burlingame, CA, US
  • Job Type: Full-Time
  • Function: IT
  • Post Date: 02/27/2021
  • Website: color.com
  • Company Address: 831 Mitten Rd, Burlingame, CA, 94010

About Color

Color’s mission is to help people lead the healthiest lives that science and medicine can offer. We launched in April 2015 with a simple, affordable genetic test to help people understand their risk for hereditary cancer. In 2017, we added coverage for hereditary heart conditions. Between them, cancer and heart disease constitute the two biggest causes of death worldwide. In September 2018, we introduced a new health area, medication response, to help people understand how their genes may influence response to certain medications.

Job Description

Named by Rock Health as the Best Digital Health Company to Work For, Color is a leading healthcare technology company. Color is building and delivering technology-enabled healthcare to millions of people. Through partnerships with public and private partners including governments, employers and health systems, Color’s infrastructure and software enables large populations to receive essential healthcare services directly where they live or work. This includes testing and telehealth services for preventive health and infectious disease management.
 
Since March 2020, Color has mobilized to address the pandemic by leveraging its platform to scale COVID-19 testing programs around the country. Color’s platform is used by more than 100 major employers, universities and public health institutions, such as the City of San Francisco, the State of California and PerkinElmer, community-based efforts in Oakland, and others, to deliver critical health programs. For more information about Color and its response to COVID-19, visit www.color.com.
 
By investing in the technology that ensures easy and affordable access to healthcare, Color is creating the infrastructure that will serve us for decades to come. Apply to join Color and do some of the most important work of your career. If you are not sure that you're 100% qualified, but are up for the challenge - we want you to apply!
 
The Bioinformatics team at Color is composed of folks with diverse previous experience in next generation sequencing (NGS) technologies, genomics, big data, cloud computing and machine learning. We are responsible for building the clinical NGS analysis pipeline, identifying novel classes of genomic variation, building tools for genomic interpretation and collaborating with R&D lab scientists to bring new products to market. As Color expands our genomics platform in new and exciting directions, we are continuing to bring on top talent in bioinformatics. 
 
We are seeking an engineer with deep experience in bioinformatics, genomics and NGS technology to grow this team. Ideal candidates will bring expertise, humility and a strong intellectual curiosity to our overall mission of democratizing access to genetic information.

How You’ll Contribute:

    • Scale our genomics platform to ingest, analyze and draw insights from a rapidly growing pipeline of genomic data.
    • Generate and pursue novel new ideas for improving our variant detection algorithms.
    • Introduce and incorporate emerging computational methodologies and infrastructure in our bioinformatics codebase. 
    • Collaborate with laboratory scientists and data scientists to translate R&D work to clinical production analyses.
    • Act as domain expert both for internal and external collaborations.

Our Ideal Candidate Will Have:

    • You have 3+ years of industry experience as a bioinformatics engineer or computational biologist (or equivalent role).
    • Proficiency/Knowledge in Python is required.
    • You maintain a high bar for quality of code and work aggressively to eliminate unnecessary duplication and awkward workarounds.
    • You're passionate about rigorous engineering practices and discipline: code reviews, automated testing, logging, monitoring, alerting, etc. 
    • You have routinely used high performance and distributed computing systems.
    • You have analyzed large sequencing datasets to identify variants across the full spectrum of size and complexity (SNV/indel, CNV, inversions, mobile element insertions, haplotypes).
    • You are familiar with genotyping based on graph alignment.
    • You effectively communicate technical information to both technical and non-technical collaborators: you identify core challenges in complex situations, explain trade offs, and incorporate feedback to make decisions using code reviews, docs, wikis, meetings, and other channels as needed.

Nice to Have:

    • You have experience building pipelines using workflow engines such as Toil and workflow languages such as CWL or WDL.
    • You have experience shipping code in a clinical production environment.
    • You are familiar with a variety of sequencing platforms: short-read SBS, linked-read, long-read, optical mapping, etc.
    • You have successfully employed relevant concepts from data science (machine learning, imputation, etc.) on biological data.
    • You have previously worked with large amounts of healthcare or genomic data.

Possible Projects To Contribute To:

    • Adopt and/or develop novel algorithms that enable extracting additional actionable clinical insights from sequencing data.
    • Build a genomics infrastructure that scales efficiently to the volume of large studies such as “All Of Us” (1 million participants).
    • Reduce complexity or remove dependencies in our clinical analysis pipeline.
    • Identify novel genomic loci associated with mono-genic diseases based on functional annotation, public databases, scientific literature, etc.
    • Track emerging COVID-19 variants to flag potential impact on our SARS-CoV-2 diagnostic assay.
#LI-MC1
 
Color is an equal opportunity employer. In accordance with anti-discrimination law, it is the purpose of this policy to effectuate these principles and mandates. Color prohibits discrimination and harassment of any type and affords equal employment opportunities to employees and applicants without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law. Color conforms to the spirit as well as to the letter of all applicable laws and regulations.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.