Scientist, Molecular Biology

Second Genome

Brisbane, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 03/04/2021
  • Website:
  • Company Address: 1700 Owens Street, 5th Floor, San Francisco, CA, 94158

About Second Genome

Second Genome is at the cutting edge of microbiome science, translating breakthrough research into medicines and other novel products that help humanity.

Our scientists and staff are true pioneers in this dynamic field. We are advancing a pipeline of novel therapies for serious diseases, while also making new breakthroughs in multiple fields of research using our one-of-a kind discovery platform. With our impact felt across industries — from healthcare and nutrition to agriculture — we are recognized as global leaders in translating rapidly emerging science into products that help humanity.

Job Description

We are a fast-paced and innovative venture-backed biotechnology company developing tomorrow’s breakthrough therapeutics at the interface of complex microbial communities and their host environments.  We are leaders in microbial ecology, metagenomics, and computer science. We love fresh approaches, we value process validation, and we welcome peer review. 


And we’re looking for a Scientist specializing in Molecular Biology.


You have a strong molecular biology background and the ability to characterize new drug candidates for our pipeline focused on IBD and Immuno-Oncology. The initial work will include testing and developing a bacterial drug delivery system and elucidating mechanism-of-action of novel proteins/peptides. This position requires a diverse set of skills, working at the interface of microbiology, biochemistry, and cell biology to enable us to move only the most promising molecules into the development pipeline.


How You’ll Impact the Company

  • You will engineer and optimize bacterial strains for drug production. 
  • You will identify new host targets through your ability to decipher protein-protein interactions.
  • You will analyze activity and stability of drug candidates, and use that information to engineer proteins/peptides to improve drug candidates.
  • You will independently analyze scientific results, troubleshoot methods, and conceive creative solutions and workflows to address challenges.
  • You will collaborate cross-functionally with Discovery, Protein Science, and Informatics teams to progress programs from lead selection through preclinical development.


What You Bring to the Role

  • You have a Ph.D. degree in a relevant Biological Science (Molecular Biology, Microbiology, Biochemistry).
  • You have expertise with common molecular biology techniques including molecular cloning, vector design, DNA and RNA extraction, qPCR, DNA sequencing.
  • You have experience with culturing and genetics of bacteria, as well as generating and analyzing mutants.
  • You have experience with protein expression and analysis (SDS-page, Western Blot, ELISA).
  • You have a background in host-bacteria interaction understanding bacterial and host cell physiology.
  • You are accustomed to providing excellent documentation with strong written and verbal communication skills.
  • You have a proven track record of accomplishments through publications, patents, etc.
  • You have experience managing and meeting project timelines.
  • You have experience managing direct reports.


Second Genome provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Second Genome complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

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Second Genome - Brisbane, CA, US
Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.