Research Associate/Sr. Research Associate, Aerosol Sciences

Translate Bio

Lexington, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 03/25/2021
  • Website: translate.bio
  • Company Address: 790 Memorial Drive Suite 203, Cambridge, MA, 02139

About Translate Bio

Translate Bio is focused on pioneering the translation of RNA science into therapeutics promoting healthy gene expression in people living with debilitating genetic diseases. The company’s RNA platforms for powering endogenous therapeutic protein production is applicable to a broad range of diseases caused by insufficient protein production, including rare diseases of the liver, lung and central nervous system (CNS).

Job Description

We are a leading mRNA therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction. Using our proprietary mRNA therapeutic platform (MRT), we create mRNA that encodes functional proteins. Our mRNA is delivered to the target cell where the cell’s own machinery recognizes it and translates it, restoring or augmenting protein function to treat or prevent disease.

At Translate Bio, we’re also passionate about our five core values: Put People First, Be Approachable, Act as One, Be Tenacious, and Be Bold. These values embody our culture and underscore our mission to bring mRNA therapeutics to all.

Job Summary

We are seeking a highly motivated and scientifically rigorous individual to join the Aerosol Sciences team as a RA/ Sr. RA. The position will focus on evaluation of nebulizers for delivery of novel mRNA formulations.

Job Responsibilities

  • Support evaluation and testing of nebulizers for delivery of mRNA formulations
  • Maintain test equipment in a calibrated state
  • Order/receive materials from vendors and manage the nebulizer parts inventory
  • Develop analytical methods for characterization of produced aerosols
  • Evaluate mRNA Lipid nanoparticle (LNP) formulations in nebulizer devices 
  • Develop cleaning and use instructions for selected devices
  • Perform experiments to evaluate device robustness.  
  • Collect data in laboratory notebooks and provide data summaries.
  • Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams

Required Skills & Qualifications

  • B.S./M.S. in Chemistry/Physical Chemistry/Chemical Engineering/Biochemistry   
  • 0 - 6 years of relevant experience in drug delivery
  • Prior experience working with orally inhaled and nasal drug products is strongly desired
  • Experience with testing of other medical devices is advantageous
  • Direct experience with messenger RNA product characterization/handling is preferred
  • Experience with characterization of aerosols is preferred (emitted dose, APSD, droplet size)
  • Proficiency in analytical techniques (Next Generation Impactor, laser diffraction,  HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry)
  • Basic understanding of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.) is desirable
  • Desire to work in a fast-paced environment
  • Excellent organizational and communication skills 
  • Strong analytical and problem-solving skills
  • Works collaboratively within group as well as within interdisciplinary teams
  • Desire to work in a fast-paced environment

Translate Bio is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.