Senior Scientist-CMC Analytical Development

Rejuvenate Bio

San Diego, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences QA/QC
  • Post Date: 03/05/2021
  • Website: www.rejuvenatebio.com
  • Company Address:

About Rejuvenate Bio

At Rejuvenate Bio, we aspire to treat aging and age-related diseases afflicting animals, such as MVD. We launched out of George Church's lab at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering at Harvard University. Our targeted gene therapies treat pets and are directed at curing specific disease states associated with old age. These therapies have the potential to extend overall health and lifespan.

Job Description

At Rejuvenate Bio, we aspire to treat aging and age-related diseases. We are a spinout from George Church's lab at Harvard Medical School and the Wyss Institute, and our goal is to treat pets with targeted gene therapies directed at curing specific diseasestates associated with old age that also have the potential to extend overall health and maximal lifespan. So, come join Rejuvenate and save all the puppies!!!!!!! (Puppy parties as celebration events are highly probable)

Duties & Responsibilities
Rejuvenate Bio is looking for a highly-motivated individual to join our energetic team and accelerate the development of our therapies. The CMC and assay developmentposition will directly support efforts to drive forward our future commercial offeringsdeveloping our GMP process. Gene therapy is at a tipping point. We have already seen remarkable strides toward curing untreatable diseases. The Sr.Scientist will be responsible for independently developing and qualifying cell-based, ELISA and qPCR assaysfor the determination of the potency and consistency of AAV vector products.In addition, the oversight of CRO's will be a responsibility of this position.The role reports to the Sr. Director of Manufacturingof Rejuvenate Bio.

Responsibilities will include:
●Setting, completing and updating milestones related to main project.
●Performing cell culture and virus creation and purification
●Developing cell based in-vitro potency assays for AAV products with either an ELISA, ddPCR/qPCR, or a protein functional readout.
●Application of statistical methods required for the evaluation of potency assays.
●Participation in transfer and validation activities for cell-based in-vitro potency assays.
●Management and oversight of a small group of Scientists and Research Associates for supporting multiple Rejuvenateprograms.
●Performing standard and advanced cloning techniques
●Executing experiments, independently and in conjunction with a small team in support of research studies
●Following laboratory protocols and safety regulations.
●Performing detailed and accurate documentation of all experiments and laboratory practices.
●Accountable for on-time, high quality results and clearly communicating progress.

Basic Qualifications
Ph.D. in virology, biology, biochemistry, microbiology, biomedical engineering, bioengineering or related field required. Experience with AAVor other biologic assay development.Demonstrated prior experience developing cell-based assays for the assessment of product potency employing ELISA, qPCR, enzymatic, and viability readouts. An understanding of statistical methods required for the evaluation of potency assays.


Additional Qualifications
2+ years of industryexperience preferred.Experience with suspension cell culture and protein production.Experience with flow cytometry, ELISAs, PCR, and microscopy. Proven ability to draft and implement lab protocols. Ability to work independently as well as in a collaborative team environment. Strong work ethic, communication skills and goal-oriented personality.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.