Senior Director, Bioinformatics


Philadelphia, PA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 04/12/2021
  • Website:
  • Company Address: 351 Rouse Boulevard , Philadelphia, PA , 19112

About Adaptimmune

Adaptimmune, a leader in T-cell therapy, is a multinational, clinical-stage biopharmaceutical company focused on developing novel immunotherapies using its proprietary SPEAR T-cell receptor platform to treat solid tumors, which has the potential to transform the treatment of cancer.

Job Description

The Senior Director of Bioinformatics (Head of function) will lead a high performing team in support of company-wide bioinformatic needs.   This role is intended to make significant contributions in maturing process efficiency, defining and delivering on bioinformatic data analysis, methods of inquiry, life-cycle and tools for the understanding biological data.  The Senior Director will guide strategic and operational projects.

This role will partner with software engineers, data engineers, data architects, scientists, data stewards and governance resources to deliver on a strategic enterprise vision around integrated bioinformatics data insight. 

The Senior Director of Bioinformatics must be at ease sorting through competing priorities, project execution, mentoring of senior and junior staff, matrix structures, multi-country responsibility, and the stand up of new enterprise capabilities to better achieve analytic outcomes.  The role will be highly visible, and therefore is expected to positively impact the overall execution of data science, data projects and delivery of analytical insight. 


Key Responsibilities

  • Partner with senior leaders across research, manufacturing, commercial and clinical functions to identify analytical needs, define analytical strategy and develop plans to achieve outcomes
  • Direct the design, development, implementation, and maintenance of the bioinformatics function
  • Lead novel biological analytical methodologies across the organization
  • Provide technical, scientific and strategic leadership to support functional decision making and analysis
  • Partner to ensure that the design and execution of bioinformatic plans, actionable findings, and governance are in place for both exploratory and rigorous outcomes
  • Establish and maintain uniform operational processes regarding high-performance computing, data handling and processing, and good programming practices across bioinformatics team

Qualifications & Experience

  • MSc Bioinformatics, Computational Biology, Information Technology or related formal informatics training in healthcare/life sciences
  • A number of years professional experience with demonstrated achievements in global senior level position
  • Exceptional seasoned management, project management and operational management experience
  • Demonstrated experience in growing and mentoring a multi-country team
  • Expertise in algorithmic implementation, pipeline, data handling, and multi-mode data manipulation
  • Familiar with specialized commercial platforms and open source apps, database, visualization, data integration and analysis tools for high dimensional data
  • Demonstrated experience in NGS and RNA-Seq, and broader biological data analysis techniques
  • Familiar with cancer genomic data sources
  • Ability to build and foster solid relationships cross-functionally - a team player
  • Excellent verbal and written communication skills; the ability to interface effectively with scientists, manufacturing and clinical staff to communicate / discuss results and ideas
  • Prior experience in biotechnology and / or pharmaceuticals industry
  • At ease working in fast paced highly ambiguous complex environment
  • Expert in one of following fields: genetics, immunology, oncology

Skills & Competencies

  • Strong leadership, organization, business partnering, analytical and scientific skills
  • Excellent communication skills, and able to clearly summarize scientific and technical content
  • Able to tell a story with the data to communicate complex ideas
  • Demonstrated experience handling high fidelity data for regulatory submissions
  • Deep understanding of experimental and analytical methodologies used in the biological space (NGS, RNA-Seq, etc.)
  • Predictive modelling, artificial intelligence, data science
  • Strong creative thinking and problem-solving skills
  • Strong in bioinformatic life-cycle from initial data source plan, through data cleaning and analysis to visualization and report out
  • Ability to lead develop customized bioinformatics tools where commercial platforms do not exist
  • Hands-on experience in the fields of bioinformatics including working with bioinformatics tools (e.g., BLAST, GATK, Cell Ranger, samtools, VEP), statistical environments (e.g., R, S+, Matlab) and various public and proprietary data repositories (e.g., TCGA, GTEx, dbGaP, Ensembl, UCSC genome browser, Array Studio)
  • Experience with manipulation, interpretation, and innovative analysis (e.g. novel algorithm development) of large biological datasets
  • Familiar with best practices, system development life cycle management, infrastructure and operations
  • Cloud computing systems (e.g. Amazon Web Services)
  • Understanding of metamodels, taxonomies and ontologies, as well as of the challenges of applying structured techniques (data modelling) to less-structured sources
  • Familiarity with master data, business intelligence, data lake, and data warehouse techniques


Routine travel to company locations


At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.