Scientist I

System1 Biosciences

San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 01/09/2021
  • Website:
  • Company Address: 1405 Minnesota Street, San Francisco, CA, 94107

About System1 Biosciences

System1 Biosciences, Inc., is a San Francisco based neurotherapeutics company that employs AI-driven phenotypic screening to discover novel drugs for complex neurological and psychiatric diseases such as epilepsy, autism, and schizophrenia, disorders for which current discovery techniques have proved least successful.

Job Description

System1 Biosciences is revolutionizing drug discovery for brain disorders by combining biotechnology, neuroscience, robotics, and machine learning techniques. We employ AI-driven phenotypic screening to discover novel drugs for complex neurological disorders such as autism and neurodegenerative diseases.

We’re building a world-class high-throughput cell culture, microscopy, and bioassay platform that requires integration of industry-standard and custom proprietary robotic systems.

Duties & Responsibilities

This role is as a core member of our Biology team, doing fundamental research for our specific disease models for various neurodevelopmental and neurodegenerative conditions. You’ll participate in project teams for partnership and internal projects and have the opportunity for independent work on new technology.

The ideal candidate must have:

  • experience in generating iPSC-based neurological disease models
  • expertise in differentiating iPSCs to neurons and/or microglia
  • success in developing and executing molecular and fluorescence-based assays
  • a track record of driving projects to completion
  • worked successfully in cross-functional teams
  • MS and 3+ years of work experience or a PhD in a biological or neurological science field, with in-depth knowledge of neurobiology, cell biology, and molecular biology
  • the ability to work full-time hours in our San Francisco office, including some weekend work

Experience working with complex systems such as organoids, other 3D models, and/or co-culture models is preferred.

We offer competitive salaries, benefits, and opportunities for professional growth in an intellectually stimulating and fast-paced environment. These include medical/dental/vision coverage, 401(k) and FSA plans, a flexible vacation policy, paid parental leave, and support for relevant training.

About System1 Biosciences:

System1 Biosciences is a San Francisco-based neurotherapeutics company founded by professors from Columbia University and UCSF, along with experienced technologists, with the support of a wide range of investors and partners. Current drug discovery techniques have proven least successful for complex neurological and psychiatric diseases, and our team combines cerebral organoid science, systems neuroscience, robotic automation, and advanced data analytics to characterize these diseases in ways never before achievable. Our team is dedicated to finding better treatments and reducing the impact of neurological and psychiatric disease for patients and their families.

System1 Biosciences is committed to creating a diverse and inclusive environment and we are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.