Head of Translational Medicine

Faze Medicines

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Clinical Research
  • Post Date: 02/14/2021
  • Website: www.fazemed.com
  • Company Address: 215 First Street, Suite 440 , Cambridge, MA , 02142

About Faze Medicines

Faze Medicines is a biotechnology company pioneering therapeutics based on the groundbreaking new science of biomolecular condensates. Our entire team is excited by the opportunity to harness this transformative moment in cell biology and translate discoveries in the lab to make a difference for patients.

Job Description

The Role:
 
The Head of Translational Medicine will be responsible for advancing the science of early development, bridging across research, preclinical and early development functions to define initial biochemical activity in first clinical indications.  S/he will be responsible for designing and implementing a strategy for optimal integration of early clinical development and for defining the paths toward clinical Proof of Concept (PoC).  
 

Responsibilities:

    • Be a key leader to guide drug discovery projects to clinical evaluation for programs focused on rare genetic diseases and/or neurodegenerative diseases.
    • Guide disease selection, pre-clinical disease validation, clinical endpoints; and act as key liaison to patient advocacy groups. 
    • Provide clinical perspectives to preclinical sciences, develop target product profiles for preclinical programs, strategically guide IND-enabling preclinical studies that will support clinical plans.
    • Relate science/mechanisms of action to expected clinical profile for indication
    • Select, validate and develop clinical biomarkers to demonstrate proof of mechanism, support dose selection and understand PK/PD relationship.  
    • Participate in defining criteria for medical needs and in new target selection.
    • Collaborate with as well as oversee consultants and third party service providers supporting the Translational Medicine program.
    • Work with senior leadership to help represent the company as a senior translational/medical spokesperson before appropriate scientific, medical, regulatory, business and other professional meetings.
    • Serve as translational medicine representative to Business Development efforts in the evaluation and implementation of partnerships, joint ventures, and in-/out-licensing opportunities.

Requirements and Qualifications:

    • M.D. is required, M.D. / Ph.D. degree is preferred 
    • Minimum of 5 years’ industry experience 
    • Clinician or clinical disease expert with background in neurodegenerative diseases 
    • Strong track record in translational medicine including hands-on experience taking small molecules and/or biologics through preclinical development into the clinic
    • Knowledge of neurodegenerative diseases and their relevance to the clinic
    • Direct experience and/or training in Myotonic Dystrophy and/or ALS preferred; additional experience in other therapeutic areas will be a plus
    • Knowledge of applied research sufficient to understand how translational science enables the evolution into Clinical Development
    • Ability to collaborate with internal and external multi-disciplinary research and development teams
    • Experience with PK/PD analysis and modeling
    • Experience developing novel approaches to clinical development in partnership with the FDA will be a plus

Required Skills:

    • Ability to oversee collaborations with CROs and academic centers
    • Extensive contacts and well-developed relationships within the academic scientific community and regulatory agency
    • Exceptional analytical and problem-solving abilities
    • Experience with the regulatory environment
    • Understanding of clinical evidence base and active research behind the use of molecular markers in treatment selection
    • Excellent written and verbal communication capabilities
We are an equal opportunity employer offering a competitive salary and benefits package.
All applicants should be legally entitled to work for any employer in the U.S.
 
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.
 
We are an equal opportunity employer offering a competitive salary and benefits package.
All applicants should be legally entitled to work for any employer in the U.S.
 
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.