Translational Sciences, Director/Sr. Director

Constellation Pharmaceuticals

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 01/06/2021
  • Website:
  • Company Address: 215 First Street, Suite 200, Cambridge, MA , 02142

About Constellation Pharmaceuticals

Constellation Pharmaceuticals is a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics that address serious unmet medical needs in patients with cancers associated with abnormal gene expression. Our integrated epigenetics platform enables us to validate targets and generate small molecules against these targets that selectively modulate gene expression in tumor and immune cells to drive anti-tumor activity. We are able to target a broad variety of epigenetic regulators using our platform and have generated development candidates acting against distinct classes of those regulators.

Job Description

Constellation Pharmaceuticals is a premier epigenetics company, focused on the discovery and development of novel, small molecules targeting chromatin regulatory proteins in tumor and immune cells for therapeutic applications in oncology. Our unique discovery platform integrates our understanding of chromatin-regulatory mechanisms with cancer and immune pathways to optimize our drug discovery activities and fully enable the clinical translation of our programs.  Our translational capabilities are currently being expanded to ensure the differentiated clinical development of our clinical and pre-clinical assets and we seek talented and experienced individuals who want to participate in developing novel cancer therapeutics.

The Translational Sciences Department is looking for an experienced group leader for our BET inhibitor program, leading the translational development of our Ph3-stage CPI-610 program through potential NDA filing and commercialization. The group leader will report to the department head of Translational Science and lead a group of 5 Ph.D. and non-Ph.D. scientists.


Summary of Responsibilities:

  • Lead a group of Ph.D. and non-Ph.D. scientists to develop and implement strategies for clinical biomarker testing, indication expansion, life cycle management, patient stratification, combination therapy, mechanism of action studies, and drug candidate differentiation
  • Represent Translational Science on the BET program core team, which leads the clinical development and life-cycle management of the CPI-0610 program; lead CPI-0610 preclinical sub-team, which include multiple preclinical functions and reports to the core team
  • Develop clinical biomarker testing strategies for all CPI-0610 clinical trials, collaborate with clinical team and clinical assay development team in clinical sample collection and testing, and communicate translational designs and findings with clinical investigators
  • Author and review the translational sections of regulatory documents as well as scientific/clinical publications, and represent CNST to present translational findings at scientific congresses and investigator meetings
  • Manage external collaborations with KOLs and clinical investigators aimed at gaining a deeper understanding of MOA and the development of patient stratification biomarkers
  • Assemble and manage a high-performance translational team to ensure successful preclinical and clinical development of our BET inhibitor program


Experience / Qualifications:

  • D. in biochemistry, cell biology, pharmacology, medical science, or related fields is required
  • At least eight years of drug development experience in industry is required
  • At least five years of management experience in industry is required, with adequate experience in managing PhD level scientists
  • Experience in leading biomarker testing in clinical trials for oncology drug development is required
  • Experience with small molecule drug development is required
  • Outstanding track record of scientific achievement and excellent soft skills are required
  • Deep understanding of epigenetics is preferred
  • NDA experience preferred

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.