Principal Scientist/Senior Scientist – Mechanistic Biology

Dyne Therapeutics

Waltham, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 12/29/2020
  • Website:
  • Company Address: 400 Technology Square 10th Floor, Cambridge, MA, 02139

About Dyne Therapeutics

Dyne was founded with a singular focus: to transform the lives of people with serious muscle diseases by pioneering muscle-targeted therapies. Our proprietary technologies provide the foundation for breakthrough treatments. We have assembled a world-class team of experts who are united by their commitment to fulfill this mission.

Job Description

Company Overview:

Dyne Therapeutics is building a leading muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. We are utilizing our proprietary FORCE™ platform to overcome the current limitations of muscle tissue delivery with modern oligonucleotide therapeutic candidates. Dyne is developing a broad portfolio of therapeutics for muscle diseases, including lead programs in myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). For more information, please visit, and follow us on TwitterLinkedIn and Facebook.

Role Summary:

Dyne is seeking an experienced and highly motivated scientific investigator to join Dyne’s Mechanistic Biology group based in Waltham, MA. The Principal/Senior Scientist will be accountable for the progress of carefully designed in vitro and in vivo studies to evaluate efficacy, pharmacodynamics, pharmacokinetics, and mechanism of action of antibody-drug conjugates. The successful candidate will be able to provide biological insights on new targets and therapeutic hypotheses to guide drug discovery efforts. The ideal candidate has an innovative attitude and is an ambitious self-starter who also enjoys working in a collaborative environment.

Primary Responsibilities Include:

  • Independently design, execute, and analyze in vitro and in vivo IND-enabling studies to characterize mechanisms of action and PK/PD profile of therapeutic candidates in relevant biological systems
  • Design, evaluate, and develop new assays to answer key muscle disease questions to ensure programs successfully progress the clinic
  • Guide development of in vitro assays to drive optimization of the FORCE™ platform
  • Work effectively with the bioconjugation and preclinical/exploratory safety teams to build a strong data package for the nomination of clinical development candidates
  • Present results in an autonomous and effective manner to senior leadership
  • Foster a positive culture of teamwork and scientific excellence
  • Accountable for proper documentation of internal and external research efforts

Education and Skill Requirements:

  • PhD in a modern field of biology with 2 - 3 years (Senior Scientist) or 4 - 6 years (Principal Scientist) of post-doctoral experience in a biotech/biopharma laboratory. Exceptional candidates with substantial academic experience as scientific investigators will be considered.
  • Ability to design, manage, and execute in vivo pharmacology studies with small rodents and non-human primates
  • Robust theoretical understanding of, and hands-on experience with, mouse models of muscle or CNS diseases is highly desirable
  • Experience working with in vitro disease models using molecular biology and histological techniques including RNA and protein extraction, immunohistochemistry, immunofluorescence, in-situ hybridization, western blot, subcellular fractionation, qPCR, and ELISA
  • Ability to work independently and manage multiple shifting priorities
  • Experience in effectively managing CROs
  • Facilitate interactions with laboratories of academic collaborators
  • Strong written and oral communication skills, exceptional organizational abilities, and aptitude for collaborative work in a fluid cross-functional research environment
  • Strong track record of research accomplishments with relevant publications, presentations, and/or patents
  • High proficiency in the use of software applications such as Prism, Excel, and PowerPoint


The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.