Enzyme Engineering Scientist


San Leandro, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 04/09/2021
  • Website: zymochem.com
  • Company Address: 1933 Davis St, San Leandro, CA, 94577

About ZymoChem

ZymoChem is a biotechnology-centric chemicals company engineering microbe-based processes for making chemicals and high-performance materials that go into everyday products. We work with industry-leading partners to develop and introduce novel bio-based products to enable high growth market opportunities where sustainability, bio-content, and high performance are key. Our mission is realized through our proprietary Carbon Conservation (C2) biotechnology platform, which enables the rapid development of scalable production processes operating at breakthrough efficiencies while delivering substantially lower costs than incumbent processes – if they exist.

ZymoChem is headquartered in the east bay area of California, with its R&D facility located in San Leandro, CA. The company is backed by Breakout Labs, SOS Ventures (Indie Bio), the Stanford StartX Fund, and ATUM; to-date, ZymoChem has raised >$6 million in funding. The company is entering a fast-paced growth mode with numerous open positions.

Job Description

The Opportunity

The Enzyme Engineering Scientist will join our rapidly growing R&D team and spearhead the Enzyme Development Group for the fast-paced, high-throughput development of superior enzymes associated with the company’s de novo-designed carbon conserving metabolic pathways. This role is a career-defining opportunity to gain experience and skills with hiring & managing a small team along with creating and implementing ZymoChem’s protein engineering pipeline with state-of-the-art techniques and tools. The Enzyme Engineering Scientist will also be a critical part of multi-disciplinary collaborations with other ZymoChem groups as well as the company’s external partners to accelerate enzyme engineering efforts and expand the company’s IP portfolio.



  • Lead multiple enzyme engineering projects in parallel, both internally as well as with ZymoChem collaborators

  • Develop in vitro and/or in vivo assays for various classes of enzymes

  • Build out the automation capabilities for high-throughput enzyme production and enzyme screening

  • Utilize state-of-the-art computational tools to enable desired enzyme engineering outcomes

  • Establish a data management system to track experimental outputs as well as implement statistical and computational analyses on large data sets

  • Collaborate with the Strain Engineering, Fermentation, and Analytics Groups toward more in-depth characterization of superior enzyme candidates in the leading production strains



  • PhD in (Bio)chemistry, Bioengineering, Biophysics, Molecular Biology, or a related discipline working directly on topics related to enzyme characterization or engineering

  • 2+ years of industrial/startup experience working directly on enzyme engineering efforts – particularly with proven results – is strongly preferred

  • Highly proficient with designing and implementing in vitro and in vivo systems for protein production and enzyme activity assays

  • Diverse knowledge base of both wet lab and computational tools (e.g., DNA-to-phenotype relationships) for delivering improved enzymes

  • Experience with molecular modeling and visualization tools such as Rosetta and PyMol, along with scripting tools (e.g., Python, R, MatLab) for analyses of large datasets

  • Hands-on expertises using automation to accelerate enzyme screening workflows

  • Scientific rigor toward continuous evaluation of experimental design, noise/variability, reproducibility, and outcomes

ZymoChem offers full-time employees a competitive base salary and benefits package, and the company is an equal opportunity employer. If this position aligns with your career aspirations, please apply using the form below.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.