Senior Scientist, In Vivo Pharmacology

Xilio Therapeutics

Waltham, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 01/20/2021
  • Website:
  • Company Address: 828 Winter Street, Waltham, MA, 02451

About Xilio Therapeutics

Xilio Therapeutics is a biopharmaceutical company focused on developing highly-potent, targeted immuno-oncology therapeutics.

Job Description

Xilio Therapeutics is a development-stage biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. The company’s tumor-selective immunotherapies are based on its proprietary technology, which maximizes the potency of proven immuno-oncology therapies and restricts their activity to the tumor to minimize peripheral side effects. The broad applicability of these therapies across cancer types means that all patients could benefit from these potentially curative medicines.

Xilio was founded in 2016 and closed a $100.5M Series B financing from blue chip venture investors in February 2020. Xilio is headquartered in Waltham, MA.


We are seeking a Senior Scientist to join our In Vivo Pharmacology group. This individual will be responsible for in vivo oncology efficacy models, and pharmacokinetic and pharmacodynamic studies for the characterization of immuno-oncology focused protein therapeutics. Management of CROs and collaboration with internal staff will be required to execute on these studies.


  • Work with Project Teams to identify the appropriate in vivo tumor models for testing the efficacy and safety of Xilio’s protein therapeutics.
  • Design and implement studies to investigate the efficacy, safety and PK/PD of protein therapeutics including analysis of data with the appropriate statistical tools
  • Meet all guidelines set forth by Xilio’s IACUC
  • Work with CROs, collaborators and partners to execute studies to support the discovery and optimization of protein therapeutics and to support translational studies to inform upon clinical development plans.
  • Identify and integrate technologies that improve or expand the ability to assess molecules in vivo by working with teammates, collaborators, vendors, and staying abreast of the literature
  • Ensure data is captured in appropriate databases and electronic laboratory notebooks
  • Regular participation and presentation at Project Team and departmental meetings
  • Provide proper training of staff and continue to explore opportunities to expand their responsibilities and capabilities
  • Manage a research associate and collaborate with other members of the In Vivo Pharmacology team 


  • Ph.D. and +5 years in the field of immuno-oncology, or other relevant fields; ideally, with 3+ years’ experience working in a CRO, biotechnology or pharmaceutical company
  • Technical experience with development, qualification, and execution of studies in syngeneic tumor models, as well as PDX and/or humanized tumor models, and IACUC documentation
  • Experience with pharmacokinetic analyses would be preferred
  • Experience with histology and/or FACS analyses of in vivo models is desirable
  • Experience writing reports for regulatory documents

Xilio offers the opportunity to work in an innovation driven, exciting biotechnology company doing ground-breaking work in the field of immuno-oncology. We offer a competitive compensation package including a base salary, annual bonus potential, stock options, 401k, healthcare benefits and paid time-off.

POSITION: Full-Time, Exempt

EEOC Statement: Xilio Therapeutics believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Xilio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.


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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.