Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms. Today, our world-class foundry is developing over 40 different organisms to make different products across multiple industries.
Core to our organism engineering pipeline is the testing and analysis of our engineered strains. We leverage high-throughput screens and selections to measure thousands of strains at a time for improved enzyme activity of key steps or increased titers of final products. Given the diversity of projects at Ginkgo, our assay development approaches must work across multiple hosts and products. Your novel screening and selection methods will lie at the center of our new high-throughput screening pipelines.
As a Small-Scale Fermentation Scientist, you’ll utilize your expertise in organism physiology and fermentation to design microtiter plate fermentation processes. You will then use these processes to screen large libraries (from hundreds to tens of thousands) of strains with robotic work cells and liquid handling workstations in the Foundry. In addition to focusing on matching physiological conditions across plates and fermentors, you will build or improve assays used to monitor strain performance which may include colorimetric, LC-MS, or GC-MS readouts. Your data science acumen will allow you to identify the most promising hits that will perform best at larger-scale fermentation.
- Develop and optimize microtiter plate microbial fermentation processes based on larger-scale fermentation processes
- Execute high-throughput screens using the plate models that you develop, and analyze your results to determine which strains would perform best in larger-scale fermentations
- Learn, apply, and incorporate automation solutions during assay and fermentation process development, execution, troubleshooting, data analysis, and reporting
- Aid in tech transfer of strains and processes to and from customers
- Investigate and identify new methods/technologies to generate reliable and reproducible data
- Adapt readily to changing project needs and develop sophisticated problem-identification and problem-solving skills
Desired Experience and Capabilities
- PhD in biology, biochemistry, bioengineering, chemistry, chemical engineering, or related field, or Master of Science/Bachelor of Science with equivalent work experience
- Deep understanding of microbial metabolism and physiology
- Previous experience with microtiter and/or lab-scale fermentation
- Familiarity with a wide range of industrially-relevant microorganisms
- Demonstrated success in process development and/or high-throughput screening
- Experience in computational analysis of biological data and large data sets using a general-purpose programming language (such as Python, R, or Matlab)
- Familiarity with software and statistical platforms for the analysis of large data sets (e.g., JMP, Tableau, Spotfire, or MODDE pro/DoE)
To learn more about Ginkgo, check out some recent press:
Ginkgo Bioworks Awarded $40MM NIH RADx-ATP Contract to Expand High Throughput SARS-CoV-2 Testing (PR Newswire)
Ginkgo Bioworks CEO on scaling up Covid-19 testing: ‘If we try, we can win’ (CNBC)
Ginkgo raises $70 million to ramp up COVID-19 testing for employers, universities (Boston Globe)
Ginkgo Bioworks Redirects Its Biotech Platform to Coronavirus (Wall Street Journal)
Ginkgo Bioworks Provides Support on Process Optimization to Moderna for COVID-19 Response (PRNewswire)
The Life Factory: Synthetic Organisms From This $1.4 Billion Startup Will Revolutionize Manufacturing (Forbes)
Synthetic Bio Pioneer Ginkgo Raises $290 Million in New Funding (Bloomberg)
Ginkgo Bioworks raises $350 million fund for biotech spinouts (Reuters)
Can This Company Convince You to Love GMOs? (The Atlantic)
We also feel that it’s important to point out the obvious here – there’s a serious lack of diversity in our industry, and that needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equality, and inclusion in all of its practices, especially when it comes to growing our team. Our culture promotes inclusion and embraces how rewarding it is to work with people from all walks of life.
We’re developing a powerful biological engineering platform, we must remain mindful of the many ways our technology can – and will – impact people around the world. We care about how our platform is used, and having a diverse team to build it gives us the best chance that it’s something we’ll be proud of as it continues to grow. Therefore, it’s critical that we incorporate the diverse voices and visions of all those who play a role in the future of biology.
It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.