Sr. Scientist –Analytical and Formulation Development

Tarveda Therapeutics

Watertown, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 01/15/2021
  • Website: tarvedatx.com
  • Company Address: 134 Coolidge Avenue, Watertown, MA, 02472

About Tarveda Therapeutics

Formerly Known as Blend Therapeutics. Tarveda creates Pentarins that are targeted miniature drug conjugates that remain miniature by design to overcome the challenges that limit the efficacy of larger antibody drug conjugates in use and development today.

Job Description

Tarveda Therapeutics is a clinical stage biopharmaceutical company developing a new class of potent and selective precision oncology medicines, which it refers to as Pentarin® miniature drug conjugates, for the treatment of patients with various solid tumors.

Tarveda’s Pentarin® miniature drug conjugates are designed to deeply penetrate solid tumors, selectively bind to the desired tumor targets and accumulate their anti-cancer payloads directly in tumor cells.

Position Summary: We are seeking a talented and passionate Senior Scientist to join our dynamic Analytical and Formulation Development Group. The successful applicant will work in multi-disciplinary teamsand will be responsible for analytical support of formulation development, analytical characterization and stability studies for drug substances and drug products to support our clinical development programs.

Working knowledge of GMP regulations, Compendia, and common industry practices in the US and EU is desirable. The ideal candidate will have experience developing Phase 1/2 stage drugs, a strong background in analytical chemistry and analytical methodology, understanding of drug product development process, and excellent communication and organizational skills.Essential Functions:

•Oversee and execute analytical method development, both internal and at CRO, analytical characterization testing, and in-process control testing
.•Lead technical projects spanning multiple initiatives in small molecule analytical and formulation development for discovery projects and CMC support.
•Contribute to the strategy and execution of in-house and outsourced stability studies for drug substances and parenteral drug products.
•Perform a batch record review, a trend analysis, and a shelf-life assessment for investigational new drugs and clinical development candidates.
•Collaborate with peers and work effectively in an energized, fast‐paced, cross‐functional, and result-oriented research team environment to deliver the objectives of Tarveda in a timely and cost-efficient manner that meets quality requirements.
•Provide strong technical expertise and hands-on experience in analytical methodologies common to the pharmaceutical industry (e.g. HPLC/UPLC, GC, MS, KF).
•Oversee the maintenance and troubleshooting of analytical instruments.
•Train junior personnel.
•Maintain good laboratory practice, safety, and record keeping.
•Author internal reports, methods, and protocols, and contribute to regulatory submissions.
•Interact closely with Biology, Chemistry, CMC, and management to provide project updates, workflow, and contributions to timelines/budget.Education and Experience:
•Ph.D. in chemistry with 1-3 years of pharma/biotech experience or M.S. with 4-8 years of experience in a related science field is required.
•Established background in analytical characterization for drug substance, intermediates,and drug product.
•Good understanding of formulation development for parenteral products, lyophilization processes, and the delivery system development.
•Having a high degree of organizational capabilities for both data and experimental scheduling.
•Experience with managing and mentoring of junior scientific staff members.Required Competencies:
•Team oriented
•Effective communicator (written and verbal)
•Detail oriented
•Independent/self-motivated
•Result oriented
•Strong sense of priorities

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This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.