Job Description
Tasks
As part of T-knife’s growing R&D team you will participate in the discovery & characterization of TCRs for preclinical development.
• Lead, supervise and motivate a research team of 3-4 people:
• Guide the design and implementation of experimental workflows, data analysis and documentation
• Train and supervise technical assistants and new scientists
• Interpret and present results to head of the department and colleagues
• Develop and coordinate research projects together with colleagues to meet project timelines
• Pursue experimental aims:
• Evaluate novel TCR target antigens for immunogenicity and therapeutic feasibility
• Generate tumor-specific TCRs from HuTCR mice by immunization and single cell sequencing
• Establish in vitro assays for immune response testing
• Characterize TCRs in primary human T cells in in vitro assays
Your Profile
• PhD in biology, biochemistry or similar
• Professional experience in a biotech company
• Experience in leading a team and supervising
• Strong background in tumor immunology, immuno-oncology, T cell biology, knowledge of TCRs/CAR-T
• Strong communication skills, team spirit and flexibility
• Translational mindset, economic and analytical thinking with a high degree of initiative and self-organization
• Comfortable working in a dynamic environment & willing to fully commit to a project
• Solid practice of laboratory methods in immunology (ELISA, FACS), cell culture and molecular biology (cloning, PCR)
• Experience with mouse experiments (handling, breeding, documentation) and in NGS advantageous
