Scientist – Assay Development Scientist


Menlo Park, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 01/21/2021
  • Website:
  • Company Address: 1505 Obrien Drive, Suite A/D, Menlo Park, California 94025, US

About Synthekine

Synthekine, a biotechnology company focused on discovery and developing best in class cytokine therapeutics

Job Description

Synthekine is a biotechnology company focused on discovery and developing best in class cytokine therapeutics to treat cancer and autoimmune diseases. The company was founded by Dr. Chris Garcia, Stanford University Professor and Howard Hughes Medical investigator. Synthekine is based on our unique insights on how cytokines bind to their receptors and how these systems can be tuned through ligand engineering. Synthekine was formed in 2019 and has raised its Series A venture capital round from Canaan Partners, Samsara Biocapital, and The Column Group, three leading Bay Area biotech venture funds. The company is based in Menlo Park, CA and has built integrated research, manufacturing, and in-vivo pharmacology capabilities.

Synthekine is advancing a deep pipeline that includes several preclinical programs, including biased versions of Interleukin-2 and Interferon Gamma. These cytokines have been tuned to decouple anticancer and anti-inflammatory activity at the molecular level, a differentiated approach to developing selective therapeutics. In addition to these pre-clinical products, Synthekine is founded on multiple therapeutic platforms, including a platform that allows for non-natural pairing of cytokine receptors, potentially resulting in novel biology and unique therapeutics.


We are looking for a talented & driven assay development scientist to play a key role in the development and execution of product specific assays for Synthekine’s various programs. Relevant assays will include SEC-HPLC, CEX-HPLC, RP-HPLC, ELISA, qPCR, peptide mapping, MS, LC-MS, SEC-MALS, Biacore, western blot, SDS-page, IEF, and other assays that may be required. The assay development scientist will play a crucial role in the characterization of both clinical drug candidates and research drug candidates. The assay development scientist may also be responsible for mentoring junior analysts. Level will be commensurate with experience.

  • Participate in the design, development, and implementation of biochemical experiments to support assay projects and development of the core protein assay platform, with specific emphasis on proteomic assays such as, ELISA, and HPLC.
  • Assay development with ELISA, immunoassay multiplexing technology, MSD (meso scale discovery). Duties include assay optimization, sample analyzing, assay troubleshooting, automation support, assay characterization and validation, generating.
  • Troubleshoot, propose next steps, or suggest alternate strategies within complex systems and assays
  • Perform installation and maintenance of laboratory instruments and equipment.
  • Authorship of analytical protocols, reports, and SOPs.
  • Communicate experimental findings accurately and concisely in both oral and written form
  • Analyze, document and report laboratory data in accordance with Synthekine’s standards and procedures
  • Present at group meetings, project team meetings and company-wide meetings
  • Advanced degree in Biochemistry, Immunology, or similar fields with 4 years post-graduate experience (persons with BS degree who have comparable depth and breadth of training and experience and who meet job-specific criteria are eligible for consideration)
  • Experience with standard molecular biology techniques strongly preferred (i.e. ELISA, protein/peptide sample prep and separation, qPCR, HPLC, SDS-PAGE, IEF, Western blot).
  • Strong written and oral communications skills, with demonstrated experience in cross-functional and timely communication
  • Strong and collaborative work ethic; must be a self-starter and persistent in achieving objectives to support Synthekine’s scientific and business goals
  • Must work well in a small team setting, with ability to work independently and collaboratively, while meeting scheduled deadlines in a fast-paced environment
  • Highly organized, exceptional attention to detail, and strong proficiency in documentation skills
  • A passion for teaching and positive mentorship a major plus

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.