Director, Computational Chemistry

Nimbus Therapeutics

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Manufacturing
  • Post Date: 03/01/2021
  • Website: nimbustx.com
  • Company Address: 784 Memorial Drive Suite 100, Cambridge, MA, 02139

About Nimbus Therapeutics

Nimbus Discovery is leveraging an asset-centric, virtual drug discovery model that exploits a breakthrough in silico technology.

Job Description

THE ROLE & RESPONSIBILITIES OF THE DIRECTOR, COMPUTATIONAL CHEMISTRY AT NIMBUS

Nimbus Therapeutics is recruiting a highly qualified computational chemist who will be working within multi-disciplinary teams to apply computational chemistry techniques, cheminformatics and molecular modeling for the purpose of advancing small-molecule drug discovery programs. The qualified candidate will be creative, detail-oriented and a problem solver with a passion for drug discovery and a track record of applying computational chemistry and cheminformatics methods to solve problems at all stages of the drug discovery and development process. Our successful candidate will be a clear communicator and an enthusiastic team player.

THE DIRECTOR, COMPUTATIONAL CHEMISTRY WILL:

  • Apply structure-based and ligand-based drug design methodology to drive project initiation and progression
  • Make key intellectual contributions and tangible contributions to progress our in-house research programs
  • Work closely with discovery scientists to inform, influence and prioritize their synthetic chemistry
  • Perform in silico tractability/ligandability assessments and assist in the prioritization of new targets
  • Design and optimize drug candidates using advanced computational techniques such as protein modeling, free energy perturbation, molecular dynamics, QSAR models, molecular docking based on X-ray or homology models, ligand-based design, library design, diversity analysis, conformational analysis and pharmacophore modeling
  • Identify and implement new computational chemistry and molecule modeling methods and apply them in our drug discovery and development process

Qualifications We Are Seeking

  • Ph.D. in computational chemistry or chemistry, biochemistry, biophysics, or a related scientific field with a computational focus plus 10+ year’s industry experience.
  • Demonstrated track record and publication record of applying in silico techniques to drive drug discovery projects or impacting hit finding activities in drug discovery
  • A comprehensive understanding of data mining and visualization, ligand and structure-based design, conformational analysis, and pharmacophore optimization
  • Demonstrated understanding of all aspects of modern drug discovery including medicinal chemistry, DMPK principles and multi-parameter optimization
  • Demonstrated experience functioning within strong multi-disciplinary project teams
  • Demonstrated experience in complex problem solving through in depth analysis of data
  • Extensive experience with scientific software such as Schrödinger/CCG/Open Eye/Cresset, Pipeline Pilot, Spotfire, as well as any other computational chemistry software useful for drug discovery
  • Programming and/or machine learning experience is a plus

A Snapshot of Nimbus

Nimbus is a ~ 40 person, biotechnology company located in the thriving biotech hub of Cambridge, Massachusetts. We transform drug development by integrating computational drug discovery techniques, a cutting-edge computational chemistry platform and other advanced technologies to design breakthrough medicines for patients.

We focus on promising targets in metabolic disease, oncology and inflammation. These include both emerging and well-validated targets that have proven intractable to others in the pharmaceutical and biotechnology industry.

Nimbus offers a fast-paced, entrepreneurial, team-focused work environment. The culture is intellectually stimulating, flexible and results-oriented.  Joining our team offers significant opportunities to grow professionally and personally.

We also offer a top-notch benefits package (health, dental, life, vacation, and employer 401K contribution). Being part of Nimbus (a Nimbi, if you’re curious), allows you to become part of a small close-knit professional team that strives to bring out the best in each other by working hard and having fun together.

JOIN NIMBUS. WE ARE MAKING A DIFFERENCE AND YOU CAN TOO.

Nimbus Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Nimbus Therapeutics does not accept unsolicited resumes from any source other than directly from candidates.

Related Jobs

Director, Computational Chemistry

Nimbus Therapeutics - Cambridge, MA, US

Senior Desktop Engineer

Nimbus Therapeutics - Cambridge, MA, US

Clinical Operations Leader

Nimbus Therapeutics - Cambridge, MA, US
Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.