Scientist, Pulmonary Biology Pharmacology

Translate Bio

Lexington, MA, US
  • Job Type: Full-Time
  • Function: Clinical Research
  • Post Date: 02/03/2021
  • Website: translate.bio
  • Company Address: 790 Memorial Drive Suite 203, Cambridge, MA, 02139

About Translate Bio

Translate Bio is focused on pioneering the translation of RNA science into therapeutics promoting healthy gene expression in people living with debilitating genetic diseases. The company’s RNA platforms for powering endogenous therapeutic protein production is applicable to a broad range of diseases caused by insufficient protein production, including rare diseases of the liver, lung and central nervous system (CNS).

Job Description

Company Overview


We are a leading mRNA therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction. Using our proprietary mRNA therapeutic platform (MRT), we create mRNA that encodes functional proteins. Our mRNA is delivered to the target cell where the cell’s own machinery recognizes it and translates it, restoring or augmenting protein function to treat or prevent disease.


At Translate Bio, we’re also passionate about our five core values: Put People First, Be Approachable, Act as One, Be Tenacious, and Be Bold. These values embody our culture and underscore our mission to bring mRNA therapeutics to all.


Job Summary


Translate Bio is seeking an experienced Scientist to join our TD team. The individual in this role will contribute to drug development efforts at TBio, particularly focused on lung diseases with high unmet need, such as idiopathic pulmonary fibrosis, pulmonary arterial hypertension, primary ciliary dyskinesia, and cystic fibrosis. He/She will oversee early drug discovery and development in vivo pharmacology studies by contributing expertise in disease animal models.


Job Responsibilities


  • Provide technical expertise in generating genetic or chemically-induced pulmonary models with a clear understanding of model development
  • Design and oversee the execution of pharmacological studies in lung disease models by applying our proprietary platform
  • Manage externalized pharmacological studies at CROs by site evaluations, protocol establishment, execution of pharmacology studies
  • Conduct downstream analyses of samples with relevant assays at the bench pertaining to the disease model 
  • Analyze data from in vivo pharmacology studies to inform decisions in a timely manner
  • Lead pharmacology and translational development roles on multi-disciplinary teams
  • Prepare reports and presentations of results from studies across the organization
  • Assume additional responsibilities as assigned

Required Skills & Qualifications

  • Ph.D. in innate immunology focused on the lung, molecular, cell/developmental, pharmacological sciences or similar with an experience in lung physiology and pulmonary disease, plus 5 - 7 years post degree experience in academic or industry setting
  • Experience performing in vivo pharmacology studies in animal models of pulmonary diseases such as respiratory infectious diseases, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, primary ciliary dyskinesia, and cystic fibrosis
  • Expertise in different routes of lung administration preferred; nebulized delivery knowledge, a plus
  • Knowledge of downstream analytics for the relevant pulmonary disease indications
  • Experience with precision cut lung slices (PCLS), a plus
  • Demonstrated ability to define pharmacological requirements for selection of development candidates
  • Ability to work in cross-functional team environment to advance programs to and through translational development
  • Work collaboratively within a group as well as within interdisciplinary teams
  • Demonstrated successful experience in working with outside CROs
  • Manages time effectively demonstrating ability to perform multiple projects at one time
  • Desire to work in a fast-paced environment
  • Excellent organizational and communication skills
  • Strong analytical and problem-solving skills
 Translate Bio is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.