Senior Scientist - Biochemical and Biophysical Characterization and Screening

Monte Rosa Therapeutics

Boston, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 01/09/2021
  • Website:
  • Company Address: 40 Guest St, Boston, MA, 02135

About Monte Rosa Therapeutics

Monte Rosa Therapeutics is a biotechnology company developing molecular glues to degrade disease-causing proteins by creating a platform that designs small molecules that reprogram ubiquitin ligases to eliminate disease drivers previously deemed undruggable.

Job Description

Monte Rosa Therapeutics is  seeking a highly motivated biochemist/biophysicist with drug discovery  experience to join the Biomolecular Sciences group. This is an exciting  opportunity to join a team responsible for the biochemical and  biophysical characterization and screening of novel small molecule  degraders. The successful candidate will be responsible for developing  and implementing a broad array of assays for lead discovery efforts in  support of Monte Rosa’s pipeline of oncology targets. The candidate  should exhibit excellent communication and collaborative skills for  working on cross-functional multi-disciplinary drug discovery teams and  have experience in managing direct reports.

Principal Duties and Responsibilities

    Contribute to the overall scientific strategy and build of the grou

    Responsible for the design and implementation of biochemical and biophysical assays to screen and characterize protein-small molecule and protein-protein interactions for multiple targets, from hit identification through mechanism of action studies

    Evaluate compounds and develop structure-activity relationships in collaboration with medicinal chemists as a part of the overall hit-to-lead process

    Proactively evaluate new screening technologies and implement into the drug discovery pipeline

    Create and implement project plans and coordinate workflow and logistics to meet project goals and milestones.

    Oversee maintenance of routine assays and generation of SOPs

    Manage tracking of reagents and transfer of data to the internal database

    Establish and manage external research at CROs

    Effectively present and communicate research findings at internal meetings and external scientific conferences

    Manage and direct the activities of research associates

Job Qualifications

    Ph.D. or MS in Biochemistry, Biophysics or a related discipline with a minimum of 5 years of relevant industry experience

    In-depth knowledge of developing assays and process to support Hit Identification and Hit to Lead activities

    Experience developing and implementing medium to high-throughput biochemical assays (e.g. FP, TR-FRET, Alpha-LISA, IF etc.)

    Experience with a broad spectrum of biophysical characterization assays (e.g. SPR, MST, ITC, NMR etc.)

    Experience in recombinant protein construct design and optimization

    Experience with screening and high throughput instrumentation for drug discovery (ECHO, scheduling software for robotic platforms)

    Experience with high throughput data management, data flow, analysis and visualization (e.g. Spotfire, CDD Vault)

    Experience in the field of targeted protein degradation (TPD) is a plus

    Track record of delivering on project and company goals

    Ability to accommodate to rapidly changing priorities and deadlines

    Experience in managing and mentoring direct reports

    Excellent communication and project leadership skills and ability to work effectively in a team setting

    Experience in managing external collaborations and CROs

    Proven track record for striving for a high level of innovation and scientific excellence

Monte Rosa Therapeutics rational approach in targeting disease-causing proteins for degradation will deliver pioneering therapies for cancer and other diseases. Delivering this new generation of treatments to the patients requires a conceptual change. Monte Rosa recognizes this urgent need and is missioned to develop innovative protein degraders as a solution. Combining deep knowledge, insight and leading-edge science, our integrated engine is built for that purpose.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.