/ Revolution Medicines hiring Scientist/Senior Scientist, Toxicology in Redwood City, CA, US

Scientist/Senior Scientist, Toxicology

Revolution Medicines

Redwood City, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 01/14/2021
  • Website: revolutionmedicines.com
  • Company Address: 700 Saginaw Drive, Redwood City, CA, 94063

About Revolution Medicines

REVOLUTION Medicines discovers and develops new drugs that harness the therapeutic potential of frontier oncology targets on behalf of cancer patients. Our innovative product engine draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches. We pay particular attention to natural products that are inherently rich with biological function as a result of natural selection and can inform and guide our discovery and development of small molecules that can modulate these targets.

Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit elusive frontier targets within notorious growth and survival pathways, with particular emphasis on RAS and mTOR signaling pathways. Our experienced team of scientists deploy this platform to validate frontier cancer targets, define sites on a target that could be drugged, and guide us toward precision medicines for cancer patients.  As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.

The Opportunity:

We are seeking a Toxicologist to lead safety strategies for small molecule discovery programs and work in close collaboration with colleagues in Research and Development to enable the advancement of portfolio programs. The ideal candidate will deliver a balanced assessment of the risk/ benefit profile associated with a drug candidate by integrating pharmacology/toxicology studies and engaging with stakeholders to align on a tractable clinical development plan. Further, the ideal candidate will:

  • Function as a project toxicologist on drug discovery and development project teams and be a strong advocate for safety assessment.

  • Design and oversee nonclinical toxicology programs and strategies to advance pipeline of small molecule cancer therapeutics from research phase through development programs.

  • Effectively implements and oversees studies outsourced to CROs, in collaboration with study operations, pharmacology, DMPK and clinical pharmacology functions.

  • Analyze, interpret, and summarize nonclinical safety data, and present and contextualize meaningful findings and recommendations to internal project teams and leadership.

  • Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making, including drafting and review of nonclinical sections of regulatory documents.

  • Develop and implement target de-risking, screening, issue mitigation, and resolution strategies for toxicities observed in vivo.

Required Experience, Skills, and Education:

  • Ph.D. degree in toxicology, pharmacology or related discipline with 3+ years of relevant biotech/pharma drug discovery/development experience in a team-facing role; DABT certification is desirable.

  • Experience preparing nonclinical safety sections supporting IND/NDA submissions using CTD format.

  • Interactions with FDA and other regulatory agencies.

  • A thorough understanding of GLP regulations and related US and ex-US regulatory guidance documents.

  • Experience with small molecules; prior experience with targeted oncology therapeutics highly desirable.

  • Strong scientific background and scientific aptitude with excellent critical thinking and scientific skills.

  • Ability to work effectively and collaboratively on cross-functional project teams; demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.

  • Excellent verbal, presentation and written communication skills.

  • Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, small company environment.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.