Associate Director/Director, Translational Sciences

Casma Therapeutics

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Post Date: 01/06/2021
  • Website:
  • Company Address: 400 Technology Square, Suite 201, Cambridge, MA, 02139

About Casma Therapeutics

We're harnessing the natural cellular process of autophagy to design powerful new medicines for a broad range of diseases.

Job Description

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Based in Cambridge, Massachusetts, Casma was launched in 2018 by Third Rock Ventures and recently completed a Series B financing led by The Column Group. .

The Role

Casma Therapeutics is seeking an experienced drug discovery scientist with deep knowledge evaluating therapeutic efficacy in rodent models for rare genetic diseases, mitochondrial diseases, metabolic diseases, muscular dystrophies, and CNS aggregation disorders. The candidate will also be responsible for defining and executing an in vivo pharmacology and efficacy strategy. Applicant should adopt a highly collaborative approach to establish strong relationships with external partners and the internal drug discovery team.  This is a unique opportunity to join an innovative early stage biotech to develop novel therapeutics to meet currently unmet medical needs.


  • Collaborate with drug discovery and biology teams to select disease indications for Casma molecules and development of in vivo strategies
  • In collaboration with the Casma team, CRO partners, and external consultants, define and execute a strategy to evaluate efficacy in in vitro disease models and in relevant rodent models
  • Design and supervise the execution of studies and fully collaborate with drug discovery team to reach critical decision points leading to nomination of development candidates
  • In collaboration with program team assist in planning and execution of IND-enabling studies and development of proof-of-concept, first-in-human clinical studies
  • Identify preclinical and clinical key opinion leaders for disease indications to guide decisions regarding Casma programs
  • Other duties, as assigned.

Requirements + Qualifications

  • 7-10 years of relevant work experience in biotech/ pharma
  • Experience collaborating with biologists and chemists to generate in vitro target validation data using genetic and pharmacological methods
  • Experience with selection and development of in vivo disease models
  • Pharmacology experience with pharmacokinetics and pharmacodynamic measures
  • Experience employing molecular profiling approaches to develop pathway-dependent biomarkers suitable for use in clinical development
  • Prior experience in successfully implementing, utilizing and leveraging outsourcing strategies with CRO partners
  • Prior experience supervising internal team members
  • Multiple examples of supporting medicinal chemistry efforts to identify develop candidates
  • Prior experience and record of accomplishment functioning in cross functional teams and willingness to adopt a hands-on approach to deliver in a start-up biotech environment
  • Experience working with patient advocacy groups preferred but not required
  • Excellent organizational skills and attention to detail
  • Clear and effective verbal and written communication skills
  • Ability to successfully participate in a highly creative and enthusiastic start-up environment
  • Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Additional preferred skills

  • Significant expertise working across multiple disease indications
  • Prior experience in design and execution of IND-enabling studies preferred
  • Extensive know-how using biochemical, molecular and behavioral endpoints is essential
  • Solid understanding of drug metabolism, PD biomarkers and endpoint correlations required

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community. Casma is proud to be one of Boston’s 2019 Best Places to Work by the Boston Business Journal and one of FierceBiotech’s Fierce15 companies of 2019.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.