Senior Research Associate/Principal Research Associate/Scientist, Medicinal Chemistry

ORIC Pharmaceuticals

South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 02/16/2021
  • Website: oricpharma.com
  • Company Address: 240 E. Grand Ave 2nd Floor, South San Francisco, CA, 94080

About ORIC Pharmaceuticals

ORIC is a pharmaceutical company dedicated to discovering and developing therapies towards overcoming resistance in cancer. It offers a small molecule antagonist of the glucocorticoid receptor, which has been implicated in resistance to various treatment modalities, including chemotherapy, immunotherapy, and anti-hormonal therapy, and across multiple cancers.

Job Description

We have an exciting opportunity for a medicinal chemist to join our dynamic research organization. The individual should possess the ability to plan and execute challenging targets independently and be familiar with novel discovery technologies. A keen interest in hypothesis driven drug discovery, strong problem-solving skills, and the ability to work in a team environment by engaging with cross-functional Scientists are key elements of the role.

Responsibilities:

  • Effectively design and synthesize drug candidates that advance SAR based on data analysis of biological, DMPK, and physicochemical properties data
  • Work closely within the Medicinal Chemistry department and with the broader project teams, to influence the progress of projects
  • Execute the synthesis, purification and characterization of small molecules efficiently
  • Develop and implement the design of synthetic routes to target compounds
  • Analyze data, interpret results and recommend appropriate action
  • Keep abreast of recent scientific developments, patents and primary literature
  • Prepare patent procedures and experimental write-ups, summaries and quantitative analyses
  • Prepare presentation materials and clearly communicate research results at internal and external meetings
  • Maintain a detailed laboratory notebook according to corporate standards and SOPs
  • Participate in keeping the laboratory environment safe and well-organized

Qualifications & Experience:

  • PhD degree in Organic or Medicinal Chemistry with 0-5 years of experience (or a Bachelor with 5-10 years of relevant experience in the pharmaceutical/biotech industry or Masters degree with 3-8 years of extensive industry experience and skills comparable to a PhD). Hiring level consistent with the experience of the candidate.
  • Strong academic and practical background in modern synthetic, organic or medicinal chemistry design and methodology
  • Solid experience and scientific understanding of modern drug discovery technologies including, molecular modeling, DMPK, metabolism and physical properties is a plus but not required
  • Demonstrable ability to work in a team environment and to multitask.
  • Strong communication skills and work ethic
  • A commitment to continuous learning and a demonstrated ability to perform in a fast-paced environment with rapidly-changing priorities

About ORIC Pharmaceuticals:
ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer.  ORIC’s lead product candidate, ORIC-101, is a potent and selective small molecule antagonist of the glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors.  ORIC-101 is currently in two separate Phase 1b trials of ORIC-101 in combination with (1) Xtandi (enzalutamide) in metastatic prostate cancer and (2) Abraxane (nab-paclitaxel) in advanced or metastatic solid tumors. ORIC’s other product candidates include (1) ORIC-533, an orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy- and immunotherapy-based treatment regimens, and (2) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the embryonic ectoderm development (EED) subunit being developed for prostate cancer.  Beyond these three product candidates, ORIC is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms.  ORIC has offices in South San Francisco and San Diego, California.  For more information, please go to http://oricpharma.com/.

Related Jobs

Scientist/Senior Scientist, Computational Biology

ORIC Pharmaceuticals - South San Francisco, CA, US

Senior/Principal Scientist, Biomarker Development

ORIC Pharmaceuticals - South San Francisco, CA, US

Senior/Principal Scientist, Translational Research

ORIC Pharmaceuticals - South San Francisco, CA, US

Principal Research Associate, DMPK/Preclinical Development

ORIC Pharmaceuticals - South San Francisco, CA, US

Senior Research Associate/Principal Research Associate/Scientist, Medicinal Chemistry

ORIC Pharmaceuticals - South San Francisco, CA, US
Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.