Translational Scientist

Constellation Pharmaceuticals

Cambridge, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 02/22/2021
  • Website:
  • Company Address: 215 First Street, Suite 200, Cambridge, MA , 02142

About Constellation Pharmaceuticals

Constellation Pharmaceuticals is a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics that address serious unmet medical needs in patients with cancers associated with abnormal gene expression. Our integrated epigenetics platform enables us to validate targets and generate small molecules against these targets that selectively modulate gene expression in tumor and immune cells to drive anti-tumor activity. We are able to target a broad variety of epigenetic regulators using our platform and have generated development candidates acting against distinct classes of those regulators.

Job Description

We are looking for an experienced and motivated translational scientist with clinical development experience to join the Translational Sciences group at Constellation to lead the development of our BET inhibitor in additional oncology indications. You will join the established BET translational team and report to the Director of Translational Sciences leading indication/biomarker identification and developing combination strategies. We are #BrighterTogether.


How you will spend your day:

  • You will be a key contributor to the BET translational sciences program, delivering scientific discoveries to guide decision-making and contributing to clinical development strategy at team meetings
  • Identifying and validating biological contexts that create a dependency on BET to aid indication/context prioritization for clinical development
  • Participating in the identification and clinical translation of biomarker assays that assess drug pharmacodynamics and allow testing of preclinical response hypotheses enabling a differentiating path for BET development
  • Supervision of external efforts with CROs and/or collaborators
  • Interpreting, summarizing and presenting research findings at internal and external scientific meetings


Key things about you:

  • You have a Ph.D. in molecular or cellular biology, or a related field, with an emphasis on cancer biology, and 3 – 7 years of industry experience, preferably in a translational sciences role supporting clinical trials; chromatin biology or epigenetics experience a plus.
  • You have peer-reviewed publications that show your broad knowledge and laboratory research experience in oncology, preferably in hematology-oncology
  • You love the details, are self-motivated and able to work solo
  • You have strong oral and written communication skills – writing reports and giving updates at team meetings is a required

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This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.