Director, Oncology Biology

Kymera Therapeutics

Watertown, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 12/29/2020
  • Website: kymeratx.com
  • Company Address: 400 Technology Square, 10Th Floor, Cambridge, MA, 02139

About Kymera Therapeutics

Kymera Therapeutics is a biotechnology company pioneering a transformative new approach to treating previously untreatable diseases. The company is advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade rather than inhibit dysregulated, disease-causing proteins. Powered by a proprietary predictive modeling capability and a game-changing integrated degradation platform, Kymera is accelerating drug discovery with an unmatched ability to target and degrade the most intractable of proteins, and advance new treatment options for patients.

Job Description

The Project Leader, Biology, will be responsible for drug discovery programs applying targeted protein degradation to previously intractable targets.  In collaboration with chemistry leaders and a multidisciplinary team, this individual will define the project strategy, and implement assays and in vivo models to refine understanding of the target in disease/TPP and drive hit-to-lead/lead-optimization work towards the identification of differentiated development candidates.  The project leader will direct and prioritize efforts at both contract research organizations and Kymera’s labs to address key questions and drive progression within aggressive timelines.

Kymera Therapeutics is a biotechnology company pioneering a transformational new modality called targeted protein degradation (TPD), leveraging the body’s own protein recycling machinery, the Ubiquitin Proteasome System (UPS), to degrade disease-causing proteins and pursue disease targets long considered undruggable. Using our proprietary Pegasus drug development platform, we are discovering and developing novel, heterobifunctional molecules, that optimize the key elements of the UPS to deliver new oral therapies to address significant, unmet medical needs.

Kymera is rapidly advancing toward the clinic with our first program in immune-inflammatory disease slated to begin clinical studies in the first half of 2021 and additional programs in oncology indications entering the clinic in the second half of 2021. The company also continues to expand the reach of its protein degrader therapies through strategic partnerships with companies including Vertex Pharmaceuticals and most recently, Sanofi. 

Kymera has recently designed new offices and lab space at the Arsenal Yards development in Watertown.  We offer free parking and a free transportation shuttle from Harvard Square during commute hours.

 

Responsibilities:

  • Lead/co-lead small molecule drug discovery programs from hit-to-lead to Development Candidate selection in collaboration with drug discovery, medicinal chemistry, and pharmacology colleagues.
  • Proactively identifies issues and problems within the project and leads the team to cross-functional solutions to drive project decisions. Collaborate on design and implementation of efficient compound testing scheme and supervise development of critical biological assays.
  • Lead efforts to understand biological mechanisms of action, develop therapeutic hypotheses, and identify biomarkers for target and pathway engagement.
  • Represent project team to internal leadership and external partners. Lead productive discussions on key scientific and strategic issues with internal and external colleagues at all levels and across disciplines.
  • Rapidly adapt to changing project priorities and manage multiple projects.

 

Qualifications:

  • PhD in Cancer biology, Pharmacology, Biochemistry, or related discipline with a minimum of 10 years of drug discovery, including demonstrated leadership of biology and project teams in the biotechnology industry.
    • A track record of driving projects to IND is strongly preferred
    • Recent experience in a scientific leadership role in small innovative companies is highly preferred
  • In-depth knowledge of cancer cell biology and techniques used to evaluate mechanisms of action of novel agents; expertise in epigenetics is a plus.
  • Experience with pre-clinical pharmacology models and integrating PK/PD and safety data into ongoing project decision making.
  • Attention to detail and proven track record in handling, analyzing, and presenting experimental data to drive decision making.
  • Experience in managing internal and external scientists.
  • Excellent verbal and communication skills.
  • Leads by example and willing to “roll up their sleeves” to help drive the project forward.

 

Kymera Therapeutics is an equal opportunity employer and welcomes all job applicants. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.