Senior to Principal Scientist, Computational Chemistry

Kymera Therapeutics

Watertown, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Post Date: 01/08/2021
  • Website:
  • Company Address: 400 Technology Square, 10Th Floor, Cambridge, MA, 02139

About Kymera Therapeutics

Kymera Therapeutics is a biotechnology company pioneering a transformative new approach to treating previously untreatable diseases. The company is advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade rather than inhibit dysregulated, disease-causing proteins. Powered by a proprietary predictive modeling capability and a game-changing integrated degradation platform, Kymera is accelerating drug discovery with an unmatched ability to target and degrade the most intractable of proteins, and advance new treatment options for patients.

Job Description

We are seeking an experienced and passionate Computational Chemist to join Kymera Therapeutics. The successful candidate will apply rigorous computational chemistry and cheminformatics approaches, in combination with medicinal chemistry design principles, to support our platform and pipeline projects. This is a truly unique opportunity to be at the forefront of the targeted protein degradation space.

Kymera Therapeutics is a biotechnology company pioneering a transformational new modality called targeted protein degradation (TPD), leveraging the body’s own protein recycling machinery, the Ubiquitin Proteasome System (UPS), to degrade disease-causing proteins and pursue disease targets long considered undruggable. Using our proprietary Pegasus drug development platform, we are discovering and developing novel, heterobifunctional molecules, that optimize the key elements of the UPS to deliver new oral therapies to address significant, unmet medical needs.

Kymera is rapidly advancing toward the clinic with our first program in immune-inflammatory disease slated to begin clinical studies in the first half of 2021 and additional programs in oncology indications entering the clinic in the second half of 2021. The company also continues to expand the reach of its protein degrader therapies through strategic partnerships with companies including Vertex Pharmaceuticals and most recently, Sanofi.

Kymera has recently designed new offices and lab space at the Arsenal Yards development in Watertown.  We offer free parking and a free transportation shuttle from Harvard Square during commute hours.



  • In close collaboration with medicinal chemists and project teams, apply a wide variety of drug-design and computational chemistry methods towards hit-finding, optimization of potency, selectivity, and ADME properties while minimizing toxicological risks.
  • Assimilate, summarize, and apply SAR understanding by leveraging physics-based and data-driven modeling technologies to address discovery challenges.
  • Contribute to the enhancement of the computational chemistry and cheminformatics infrastructure by developing, implementing, and deploying state-of-the-art computational tools and workflows.
  • Contribute to the design and implementation of new technologies and approaches to drugging traditionally intractable targets.


  • PhD, or equivalent, in the field of chemistry or computational chemistry with 5+ years of experience working in small-molecule drug discovery teams in a pharma or biotech setting.
  • Demonstrated ability to leverage modern computational chemistry and cheminformatics approaches, including structure/ligand/fragment-based design, virtual screening, MD simulations, and machine-learning in solving drug discovery challenges.
  • Strong understanding of Biology, Medicinal Chemistry, and DMPK principles.
  • Ability to independently solve problems, to think critically and creatively as part of a fast-paced and multidisciplinary team.
  • Attention to detail, commitment to quality and a team player mentality.
  • Experience with Schrodinger, MOE, Dotmatics, and either KNIME or Pipeline Pilot is a plus.
  • Proficiency in Python and the Linux environment.
  • Excellent organizational skills and ability to multi-task in an extremely fast-paced environment.
  • Ability to communicate clearly and concisely with all stakeholders.

Personal Attributes:

  • Strong sense of urgency to help bring new and more effective medicine to patients.
  • Passion for drug discovery and to help accelerate the drug discovery and development process.
  • Goal-driven, operates with a sense of urgency, highly collaborative, open-minded, data-driven, creative
  • Ability to dive deep into the details while focused on the big picture.
  • Persistent in the face of obstacles and uncertainty, flexible, self-aware of strengths and weaknesses, brutally objective in the evaluation of data and strongly optimistic about overcoming challenges.
  • Excellent oral and written communication skills.


Kymera Therapeutics is an equal opportunity employer and welcomes all job applicants. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

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Disclaimer: Local Candidates Only
This company does NOT accept candidates from outside recruiting firms. Agency contacts are not welcome.