Job Description

About Us:
Entact Bio is developing a novel class of precision medicines that enhance the function of beneficial proteins. Launched by a founding team deeply rooted in deubiquitylase (DUB) biochemistry, chemical biology, disease biology, and small-molecule drug development, Entact has built its proprietary Encompass™ platform to create enhancement-targeting chimeric (ENTAC™) medicines. ENTACs leverage the natural ability of DUBs to regulate and to enhance protein function, By harnessing the power of DUBs, Entact is expanding the universe of treatable diseases and creating new options for patients who are underserved by current therapeutic modalities.

We are seeking a computational chemist and modeler to join the Molecular Discovery group. The successful candidate will shape our computational chemistry strategy and help to drive programs from hit discovery to hit-to-lead, lead optimization, and development candidate selection. The successful computational chemist will help to develop the molecular basis for our Encompass™ platform while interfacing with a team of scientists in medicinal chemistry, structural biology, biophysics and biochemistry, cell biology, and research informatics to bring forward new therapies.
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Responsibilities:

• Leverage structure-based methods to design and prioritize compounds in collaboration with chemistry, structural biology, and Lead Discovery groups
• Design and execute virtual screening campaigns
• Develop models to predict properties of bRo5 compounds
• Work with leadership to develop strategy for employing computational chemistry at Entact
• Collaborate and effectively work cross functionally
• Effectively communicate scientific progress to internal project teams and external audiences
• Foster a culture of inclusion and scientific curiosity

Who You Are:

• Computational chemist who has successfully employed cutting edge tools to drive drug discovery programs towards the clinic
• Expert-level knowledge of modern concepts in computational drug discovery, including docking, pharmacophore-based drug design, and water map
• Experience with cheminformatics and compound library design a plus
• Strong communicator
• Organized with effective time management and planning skills
• Highly collaborative
• Driven and conscientious: proactively identifies opportunities to contribute scientifically and organizationally to promote a culture of innovation and inclusion

Qualifications:

• Ph.D. in computational chemistry or related field with 7+ years of experience in the drug industry
• Experience in heterobifunctional and induced proximity space a plus

Entact is home to scientists, entrepreneurs, drug creators, and problem solvers, all inspired by the idea that even when you’re ill there’s something intact within your cells that can help you get well. As a member of this diverse and growing team, you will lend your insights, passion and talent, to the mission of translating this vision into novel therapeutics for the patients who need them the most.

We are an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.