Career | Manager/Scientist, Head of Oligonucleotide Operations | Korro Bio

Manager/Scientist, Head of Oligonucleotide Operations

Korro Bio

Cambridge, MA, US

  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Therapeutics
  • Post Date: 11/12/2024
  • Website: www.korrobio.com
  • Company Address: One Kendall Square, Building 600-700, Suite 6-401, Cambridge, Massachusetts 02139, US

About Korro Bio

Korro Bio was founded to turn extraordinary scientific insights into life-altering new treatments for patients. We harness the body’s natural RNA editing machinery to make precise, single-base RNA edits to modulate protein function, addressing the medical needs of patients.

Job Description

Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.
 
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
 
Position Summary: We are seeking a collaborative, smart and creative chemist who will lead the small, mid, and large-scale oligonucleotide synthesis teams and compound management operations at Korro. Key contributions for this position include management of an oligonucleotide synthesis workstream, providing cutting edge chemistry insights into oligonucleotide synthesis to enable platform and therapeutic program development, and acting as a SME resource for our internal Focus Teams. Core competencies include an ability to function in an interdisciplinary and fast-paced startup environment coupled with a proactive and collaborative approach. The role will include management responsibilities and the potential for significant career growth. This position reports to the Chief Operating Officer and will be based in our Cambridge, MA location.

Key Responsibilities:

    • Provide chemistry development leadership to advance cutting-edge research of oligonucleotide therapeutics.
    • Build and maintain a workstream based around our synthesizers to provide non-GMP oligonucleotides to support drug discovery and early preclinical development.
    • Oversee and manage small scale, medium scale, large scale oligonucleotide synthesis and compound management operations.
    • Manage delivery schedules and timelines for oligonucleotide production against the expectations of internal and external stakeholders.
    • Contribute to the lead discovery and optimization of oligonucleotides for therapeutic drug development as a core member of the oligonucleotide team.
    • Contribute to synthesis operations by being hands-on in the laboratory and lead matrix project teams within a dynamic cross-functional drug discovery environment.
    • Manage purchasing and external vendors and CDMOs.
    • Serve as a role model for junior scientists, and a champion for scientific rigor within an open, supportive, and data-driven corporate environment.
    • Effectively communicate strategy, results and plans to Korro’s leadership, R&D teams, and external audiences.

Required Qualifications:

    • Manager/ Scientist in a scientific field with at least 6+ years of relevant experience in a drug discovery and development environment.
    • Familiarity with oligonucleotide synthesizers such as Mermade 192, and associated downstream analytics and processing equipment for purification, desalting and lyophilization.
    • Demonstrable track record in the synthesis of oligonucleotides and oligonucleotide conjugates for applications as therapeutics.
    • Adept at troubleshooting problems associated with oligonucleotide synthesis processes.
    • Experience building and maintaining close working relationships with internal and external stakeholders, including CDMOs.
    • Experience managing direct reports, Leadership, and people development skills.
    • Must be capable of high-quality technical writing and review of source documents to support regulatory filings.
    • Excellent verbal communication skills.
Benefits:  Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.

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