Career | Director, Preclinical Development | Icosavax

Director, Preclinical Development


Seattle, WA, US / Remote

  • Job Type: Full-Time
  • Function: Clinical Research
  • Industry: Therapeutics
  • Post Date: 01/19/2023
  • Website:
  • Company Address: 1930 Boren Ave, Suite 1000, Seattle, Washington, 98101

About Icosavax

Vaccines for respiratory syncytial virus and other severe respiratory diseases

Job Description

SUMMARY: Icosavax, Inc. (NASDAQ: ICVX) is a publicly traded biopharmaceutical company leveraging its innovative VLP platform technology to develop vaccines against infectious diseases, with an initial focus on life-threatening respiratory diseases. Icosavax’s VLP platform technology is designed to enable multivalent, particle-based display of complex viral antigens, which it believes will induce broad, robust, and durable protection against the specific viruses targeted. Icosavax’s pipeline includes vaccine candidates targeting respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based in Seattle, Icosavax was formed in 2017 to advance the breakthrough VLP technology from the Institute for Protein Design at the University of Washington with the goal to discover, develop, and commercialize vaccines against infectious diseases.

The Icosavax preclinical development group is seeking a Director level scientist with a strong background working with bacterial pathogens to help progress our preclinical pipeline and provide leadership in our vaccine efforts. The Director, Preclinical Development will help define and execute criteria for advancing pipeline programs through preclinical development, identify potential external collaborations and oversee internal studies. The Director will also collaborate with internal teams and external vendors on development projects. The role is expected to help grow the scientific team in Seattle and contribute to the broader company at large.


  • Develop vaccine candidates against pipeline targets and drive them through pre-clinical validation to advance from research and into development
  • Work with internal and external partners and vendors to evaluate VLP-based vaccine candidates and adjuvants in animal models
  • Design, carry out, interpret, and communicate experiments that integrate cutting edge immunology and vaccine science to support candidate development
  • Support the development of Icosavax’s pipeline strategy in conjunction with internal functions and our Scientific Advisory Board
  • Contribute broadly to the work of the group, including supervision of junior colleagues, research into multiple vaccine candidates, management of laboratory activities and fulfillment of compliance obligations.
  • Provide expert input into internal documents and external patent applications, regulatory submissions, scientific papers and other communications for priority programs, including RSV/hMPV, Influenza, SARS2 and any new program areas.
  • Support and promote Icosavax’s core values and mission.


  • PhD in microbiology, immunology or related field is required
  • 8+ years industry experience including vaccine development experience
  • Practical knowledge of immune responses to vaccines and experience advancing vaccine candidates through preclinical evaluation into development
  • Experience with antigen validation in animal models
  • Experience managing in vivo preclinical studies at CROs
  • Experience in laboratory management and supervision of laboratory personnel
  • Strong verbal/written communication and organizational skills
  • Ability to work independently in a fast-paced start-up environment


  • Manual dexterity required to operate office equipment (i.e. computers, phones, etc.).


  • Location: Seattle, WA. Remote placement may be considered
  • Must be eligible to work in the USA
  • To reduce the presence and severity of COVID-19 cases in the workplace and in our communities, Icosavax requires all newly hired employees to be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state and local law

The salary range for this position is $175,000 – $230,000 per year; the base salary will be determined based on knowledge, skills, education, and experience relevant to the role. Employees are offered health insurance (medical, dental, vision), health savings account with company contribution, flexible spending account, life insurance, short- and long-term disability, employee stock purchase plan, 401(K) plan with company contribution, vacation, sick and safe time, company holidays and floating holidays.

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